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Table 3 Incidence rates of T2DM by statin exposure status and crude and adjusted hazard ratios

From: Statins and the risk of type 2 diabetes mellitus: cohort study using the UK clinical practice pesearch datalink

  Nº of subjects Incident T2DM per 1000 person-years (95% CI) Hazard ratio (95% CI) crude Hazard ratio (95% CI) fully adjusted* Hazard ratio (95% CI) adjusted for age and propensity score**
Exposed Unexposed
All sample 2,016,094 24.24 (24.04-24.44) 11.95 (11.86-12.04) 1.99 (1.97-2.01) 1.57 (1.54-1.59) 1.57 (1.55-1.60)
PS [5-95%] 1,448,993 23.90 (23.69-24.11) 12.2 (12.01-12.31) 1.91 (1.89-1.94) 1.56 (1.54-1.59) 1.57 (1.54-1.59)
Stop 2,016,094 25.32 (25.71-26.14) 11.95 (11.86-12.04) 2.13 (2.11-2.16) 1.70 (1.67-1.72) 1.71 (1.68-1.73)
  1,448,993 25.54 (25.32-25.77) 12.20 (12.10-12.31) 2.05 (2.02-2.07) 1.69 (1.66-1.71) 1.70 (1.67-1.72)
Change 2,016,094 29.38 (29.14-29.63) 12.13 (12.04-12.21) 2.42 (2.40-2.45) 1.90 (1.87-1.93) 1.91 (1.88-1.93)
  1,448,993 28.98 (28.73-29.24) 12.39 (12.28-12.50) 2.33 (2.31-2.36) 1.90 (1.87-1.93) 1.91 (1.88-1.94)
First 2,016,094 23.80 (23.15-24.47) 9.69 (9.48-9.91) 2.45 (2.37-2.54) 2.15 (2.05-2.25) 2.14 (2.05-2.25)
6 months 1,448,993 23.92 (23.23-24.62) 9.86 (9.59-10.13) 2.43 (2.33-2.52) 2.18 (2.08-2.29) 2.18 (2.07-2.29)
After 2,003,499 24.28 (24.07-24.89) 12.28 (12.37-24.49) 1.95 (1.92-1.97) 1.51 (1.49-1.54) 1.52 (1.49-1.54)
6 month 1,436,377 23.89 (23.68-24.11) 12.54 (12.43-12.66) 1.86 (1.84-1.89) 1.50 (1.47-1.53) 1.51 (1.48-1.53)
  1. PS – propensity score; Stop – observation periods censored at time of statin withdrawn Change – observation periods censored at time exposure status changed.
  2. All the variables in Table 1 were included in propensity score model. *Full model: adjusted for age, gender, propensity score, post index date diagnosis of hepatic disease and family history of diabetes. **Final model: adjusted for age and propensity score.