Representative MRIs showing plaque lipid depletion in right common carotid artery over 2 years. The lumen in red, outer wall boundary in blue and lipid content in yellow of the carotid artery were identified and outlined in post-contrast T1W images. LRNC demonstrate isointense on pre-contrast T1W images and TOF, and was detected as non-enhanced areas (relative to surrounding tissues) on CET1W images with the corresponding pre-contrast T1W images used as reference. Regression in LRNC at the same location was found between the baseline, 3 months, 12 months and 24 months MRI scans. MRI = magnetic resonance imaging; LRNC = lipid-rich necrotic core; TOF = time-of-flight; T1W = T1-weighted; T2W = T2-weighted; PDW = proton-density-weighted; CET1W = contrast enhanced T1-weighted.