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Table 3 Multiple regression of echocardiographic measures in adulthood on measures of adiposity in childhood and change in adiposity from childhood to adulthood

From: Impact of adiposity on cardiac structure in adult life: the childhood determinants of adult health (CDAH) study

  

Males

Females

  

Model 1

Model 2

Model 1

Model 2

Body mass index (BMI)

Regression coefficient

95% CI

P

Regression coefficient

95% CI

P

Regression coefficient

95% CI

P

Regression coefficient

95% CI

P

LVM (g)

Childhood BMI

0.46

0.23 to 0.70

<0.001

0.41

0.14 to 0.67

0.003

0.44

0.30 to 0.58

<0.001

0.53

0.34 to 0.72

<0.001

 

Change in BMI

0.30

0.08 to 0.52

0.009

0.27

0.04 to 0.51

0.023

0.29

0.14 to 0.44

<0.001

0.39

0.20 to 0.58

<0.001

Waist circumference (WC)

            

LVMI (g/m2.7)

Childhood WC

0.04

−0.01 to 0.09

0.10

0.04

−0.02 to 0.09

0.213

0.10

0.06 to 0.14

<0.001

0.13

0.08 to 0.18

<0.001

 

Change in WC

0.04

−0.00 to 0.08

0.072

0.04

−0.01 to 0.08

0.088

0.08

0.04 to 0.13

<0.001

0.13

0.07 to 0.18

<0.001

Fat mass (FM)

            

LVMI (g/m2.7)

Childhood FM

0.04

−0.01 to 0.10

0.109

0.04

−0.02 to 0.10

0.223

0.11

0.06 to 0.16

<0.001

0.15

0.09 to 0.22

<0.001

 

Change in FM

0.03

−0.02 to 0.07

0.287

0.03

−0.02 to 0.08

0.237

0.07

0.03 to 0.12

0.002

0.11

0.05 to 0.16

<0.001

Skin fold thickness (SFT)

            

LVMI (g/m2.7)

Childhood SFT

0.02

−0.03 to 0.07

0.462

0.01

−0.06 to 0.07

0.827

0.09

0.04 to 0.15

<0.001

0.13

0.06 to 0.20

<0.001

 

Change in SFT

0.00

−0.04 to 0.05

0.901

0.01

−0.05 to 0.06

0.844

0.06

0.02 to 0.11

0.009

0.10

0.04 to 0.16

0.002

  1. Model 1 - contains childhood adiposity and change in adiposity as predictors. Model 2 - as Model 1 but adjusted for confounding factors in adulthood: age, fitness, triglycerides and total cholesterol). LVM - Left ventricular mass. BMI, FM and LM data are ranked by age (separately in males and females) to account for the impact of age on growth among children.
  2. Categories of overweight and obese for BMI were calculated using age and sex specific cut-points in childhood and according to the international standard definition in adulthood (overweight BMI ≥25 and obese ≥30). The highest quartile of each childhood and adult measure of adiposity (waist circumference, skin fold thickness and fatmass) measured separately in males and females) were used to define overweight and obese (age and sex specific).
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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