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Table 4 Secondary outcome measures

From: The impact of omega-3 polyunsaturated fatty acid supplementation on the incidence of cardiovascular events and complications in peripheral arterial disease: a systematic review and meta-analysis

Outcome

No. of trials

No. of events/total patients in cohort

Effect estimate (95% CI)

I 2

Omega-3 PUFA

Control

Myocardial Infarction (Leng 1998 [34], Ishikawa 2010 [38])

2

6/156

8/132

Peto OR, 0.64 (0.22, 1.88)

0%

Cardiovascular Death (Leng 1998 [34], Ishikawa 2010 [38])

2

5/156

7/132

Peto OR, 0.60 (0.19, 1.90)

0%

Stroke (Leng 1998 [34])

1

3/60

1/60

Peto OR, 2.79 (0.38, 20.31)

NE

Angina (Ishikawa 2010 [38])

1

5/117

8/106

RR, 0.57 (0.19, 1.68)

NE

Adverse Effects

     

 All Adverse Events (Gans 1990 [37], Leng 1998 [34])

2

17/76

21/76

RR 0.81 (0.48, 1.38)

NE

 Gastrointestinal Upset (Leng 1998 [34])

1

30/60

19/60

RR 1.58 (1.01, 2.48)

NE

Revascularization Surgery (Leng 1998 [34], Ishikawa 2010 [38])

2

9/156

13/132

RR, 0.81 (0.13, 4.91)

59%

Amputation (Leng 1998 [34])

1

0/60

1/60

Peto OR, 0.14 (0.00, 6.82)

NE

Pain-Free Walking Distance (Gans 1990 [37], Leng 1998 [34], Carrero 2005 [35], Carrero 2006 [36])

4

95

88

MD, 115.40 (-42.24, 273.05)

89%

Maximum Walking Distance (Gans 1990 [37])

1

16

16

MD, -26.00 (-71.92, 19.92)

NE

  1. Walking distances (mean differences) are expressed in metres.
  2. CI: confidence interval; MD: mean difference; NE: not estimable; OR: odds ratio; RR: risk ratio; I 2: I-squared.