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Table 4 Hazard ratios and 95% confidence intervals of atrial fibrillation by birth weight category, stratified by race, ARIC study, 1996-2008

From: Birth weight and the risk of atrial fibrillation in whites and African Americans: the Atherosclerosis Risk In Communities (ARIC) study

 

Birth weight categories

 

Whites (N = 8,022, AF events = 743)

Low

Medium

High

P for trend

AF events, N

38

624

81

 

Person-years

3,471

70,183

9,304

 

Incidence Rate* (95% CI)

10.9 (7.9-14.9)

8.9 (8.2-9.6)

8.7 (7.0-10.8)

 

Model 1

1.35 (0.97, 1.88)

1 (ref.)

0.92 (0.73, 1.16)

0.10

Model 2

1.30 (0.94, 1.81)

1 (ref.)

0.92 (0.73, 1.16)

0.13

Model 3

1.38 (0.99, 1.92)

1 (ref.)

0.79 (0.63, 1.00)

0.007

African Americans (N = 2,110, AF events = 139)

Low

Medium

High

 

AF events, N

11

111

17

 

Person-years

1,191

18,798

1,791

 

Incidence Rate* (95% CI)

9.2 (4.9-16.0)

5.9 (4.9-7.1)

9.5 (5.7-14.9)

 

Model 1

1.51 (0.81, 2.81)

1 (ref.)

1.64 (0.98, 2.74)

0.55

Model 2

1.49 (0.80, 2.78)

1 (ref.)

1.75 (1.04, 2.93)

0.44

Model 3

1.60 (0.86, 2.99)

1 (ref.)

1.37 (0.80, 2.34)

0.97

  1. *Incidence rate per 1000 person years.
  2. Model 1: Cox proportional hazards model adjusted for age and gender.
  3. Model 2: As model 1, additionally adjusted for study center, income, and education.
  4. Model 3: As model 2, additionally adjusted for diabetes, systolic blood pressure, hypertension medications, smoking, height, body mass index, prevalent. myocardial infarction and heart failure.