Table 2 Eligibility criteria

I. Informed consent for participation

I. Lacks capacity to consent for him or herself

II. Severe aortic stenosis

  i. AVA <0.8 cm²

II. Pre-existing neurological impairment

  ii. Mean aortic valve gradient >40 mmHg

  i. Modified rankin score ≥ 3 (i.e. moderate disability; requiring some help, but able to walk without assistance)

  iii. Peak jet velocity >4 m/s

III. Planned TAVI or SAVR

IV. High-surgical-risk

III. Contraindication to MRI (including incompatible metallic prosthesis/foreign body, inability to lie flat, claustrophobia requiring sedation)

  i. STS score >8%

  ii. Logistic EuroSCORE >20%

  iii. Logistic EuroSCORE II >10%

IV. Non or poor English-speaking due to nature of and unknown validity in such populations cognitive testing

V. Previous aortic valve repair/replacement

VI. Coronary artery disease requiring revascularisation (including patients undergoing combined AVR and CABG)