Ability of ambulatory ECG-based T-wave alternans to modify risk assessment of cardiac events: a systematic review

Table 2 Test characteristics of AECG-based TWA

Study	End Point	HR (95% CI)	P value	TWA Pos %	TWA Neg %	Cut-off value (μV)	Lead	Method
Sakaki et al. 2009 [19]	Cardiac mortality^*	17.1 (6.3–46.6)	P <0.0001	18	82	65	V1 or V5	MMA
Sulimov et al. 2012 [20]	SCD	5.01 (1.5–17.0)	0.005	41	59	53.5	-	MMA
Yu et al. 2012 [21]	SCD	15.07 (2.88-78.68)	0.0031	22	88	47	V2 or V5	MMA
Monasterio et al. 2012 [22]	Cardiac mortality	1.44 (0.97–2.13)	0.068	24	76	3	-	LLR
Hoshida et al. 2013 [18]	Fatal arrhythmic events	5.8 (1.6–20.8)	0.0072	5	95	64	V1 or V5	MMA

Abbreviations: AECG ambulatory electrocardiogram, HR hazard ratio, MMA modified moving average, Neg negative, Pos positive, SCD sudden cardiac death, - not stated. ^*One patient who received ICD defibrillation therapy was included.

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