Figure 7

Beta-blocker carvedilol treatment helps normalize activity levels of enzymes implicated in the LV energy metabolism in 6-month AR rats. Indexed (i) heart weight was corrected for the tibial length. HADH (hydroxyacyl-Coenzyme A dehydrogenase), HK (hexokinase) PFK (phosphofructokinase), citrate synthase (CS) and carnitine palmitoyl transferase (CPT) enzymatic activities were measured in LV homogenates as described in the Methods. Results are expressed as mean ± SEM (n = 9-12/group) in μmoles/min/mg of tissue. *p < 0.05, **p < 0.01 and ***p < 0.001 between sham and AR groups and ¶p < 0.05 between AR and AR-Carv groups.