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Table 3 Predictors of deep vein thrombosis identified by uni- and multi-variate Cox regression analysis

From: Metformin use in patients with type 2 diabetes mellitus is associated with reduced risk of deep vein thrombosis: a non-randomized, pair-matched cohort study

 

Univariate analysis

Multi-variate analysis

 

HR (95% CI)

P

HR (95% CI)

P

Age, per year

1.032 (1.010-1.054)

0.004

1.031 (1.009-1.053)

0.004

Male gender

1.361 (0.812-2.282)

0.242

1.577 (0.934-2.661)

0.088

Hypertension

1.611 (0.942-2.755)

0.082

1.007 (0.541-1.874)

0.983

CAD

2.956 (1.570-5.564)

0.001

2.208 (1.026-4.751)

0.043

Hyperlipidemia

1.290 (0.635-2.621)

0.481

0.921 (0.407-2.084)

0.844

Cancer

2.694 (1.159-6.263)

0.021

1.598 (0.657-3.888)

0.301

Fracture

2.495 (1.185-5.251)

0.016

1.918 (0.899-4.094)

0.092

Major surgery

4.055 (2.057-7.996)

<0.001

3.161 (1.535-6.510)

0.002

Aspirin

1.315 (0.598-2.891)

0.496

0.703 (0.291-1.701)

0.435

Dipyridamole

1.014 (0.368-2.797)

0.978

0.728 (0.257-2.063)

0.550

Statin

1.667 (0.604-4.596)

0.324

1.553 (0.499-4.836)

0.448

Metformin

0.395 (0.223-0.700)

0.001

0.427 (0.240.0.758)

0.004

  1. CAD indicates coronary artery disease.
  2. Fracture includes traumatic or pathological fracture involving upper or lower limbs, spine and pelvis.
  3. Major surgery includes cardiothoracic, abdominal, pelvic surgery or orthopedic surgery of lower limbs.