Skip to main content

Table 4 Multiplicative and additive gene-environmental interactions analysis between T2DM and CDKN2A/B (rs10757274) on MI risk

From: Interaction of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case–control study in Chinese population

  

Frequencies (%)

    

Genotype

T2DM

Controls (N = 308)

MI patients (N = 502)

ORadd a(95% CI)

p add

ORmulti a(95% CI)

p multi

rs10757274

     

1.63(0.78,3.44)

0.197

AA

No

22.52

12.67

reference

   

GG/GA

 

53.31

48.69

1.60 (1.04,2.46)

0.0329

  

AA

Yes

10.26

10.87

1.68 (0.92,3.08)

0.0943

  

GG/GA

 

13.91

27.77

4.38 (2.56,7.47)

<0.0001

  

RERI

   

2.10 (0.18,4.03)

   

API

   

0.48 (0.19,0.77)

   

S

   

2.65(1.01,6.94)

   
  1. aAdjusting for age, gender, ethnicity, BMI, smoking and drinking habits as covariates.
  2. p add : p-value from additive gene-environmental interactions analysis.
  3. p multi : p-value from multiplicative gene-environmental interactions analysis.
Back to article page

BMC Cardiovascular Disorders

ISSN: 1471-2261

Contact us