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Table 4 Multiplicative and additive gene-environmental interactions analysis between T2DM and CDKN2A/B (rs10757274) on MI risk

From: Interaction of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case–control study in Chinese population

   Frequencies (%)     
Genotype T2DM Controls (N = 308) MI patients (N = 502) ORadd a(95% CI) p add ORmulti a(95% CI) p multi
rs10757274       1.63(0.78,3.44) 0.197
AA No 22.52 12.67 reference    
GG/GA   53.31 48.69 1.60 (1.04,2.46) 0.0329   
AA Yes 10.26 10.87 1.68 (0.92,3.08) 0.0943   
GG/GA   13.91 27.77 4.38 (2.56,7.47) <0.0001   
RERI     2.10 (0.18,4.03)    
API     0.48 (0.19,0.77)    
S     2.65(1.01,6.94)    
  1. aAdjusting for age, gender, ethnicity, BMI, smoking and drinking habits as covariates.
  2. p add : p-value from additive gene-environmental interactions analysis.
  3. p multi : p-value from multiplicative gene-environmental interactions analysis.