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Table 3 GMDR models of gene-environmental interactions on MI risk

From: Interaction of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case–control study in Chinese population

Modelsa

Prediction accuracy

CVC

p sign

p perm

T2DM

0.5815

10/10

0.0010

<0.001

T2DM, rs10757274

0.5918

10/10

0.0107

<0.001

T2DM, rs10757274, rs6903956

0.5796

10/10

0.0107

<0.001

T2DM, hyperlipidemia, rs10757274, rs6903956

0.5815

9/10

0.0547

<0.001

T2DM, hyperlipidemia, hypertension, rs10757274, rs6903956

0.5692

10/10

0.0547

0.008

  1. aAdjusting for age, gender, ethnicity, BMI, smoking and drinking habits as covariates.
  2. p sign: p-value from sign test.
  3. p perm: p-value from 1000 times permutation test.