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Table 3 GMDR models of gene-environmental interactions on MI risk

From: Interaction of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case–control study in Chinese population

Modelsa Prediction accuracy CVC p sign p perm
T2DM 0.5815 10/10 0.0010 <0.001
T2DM, rs10757274 0.5918 10/10 0.0107 <0.001
T2DM, rs10757274, rs6903956 0.5796 10/10 0.0107 <0.001
T2DM, hyperlipidemia, rs10757274, rs6903956 0.5815 9/10 0.0547 <0.001
T2DM, hyperlipidemia, hypertension, rs10757274, rs6903956 0.5692 10/10 0.0547 0.008
  1. aAdjusting for age, gender, ethnicity, BMI, smoking and drinking habits as covariates.
  2. p sign: p-value from sign test.
  3. p perm: p-value from 1000 times permutation test.