Table 2 Association analysis of genetic polymorphisms with MI risk
Chromosome location | Closest gene | SNPs | Genotypes | Genotype frequencies (%) | Without adjustment | With adjustment | |||
|---|---|---|---|---|---|---|---|---|---|
Controls (N = 308) | MI patients (N = 502) | OR (95% CI) | p | ORa(95% CI) | p a | ||||
6P24 | ADTRP | rs6903956 | GG | 85.23 | 79.30 | reference | |||
GA | 13.40 | 18.74 | 1.50 (1.00,2.27) | 0.0525 | 1.55 (0.99,2.43) | 0.0556 | |||
AA | 1.37 | 1.96 | 1.53 (0.47,5.03) | 0.4813 | 1.04 (0.30,3.59) | 0.9522 | |||
AA/GA | 14.78 | 20.70 | 1.51 (1.01,2.23) | 0.0423 | 1.49(0.97,2.29) | 0.0678 | |||
9P21 | CDKN2A/B | rs10757274 | AA | 32.78 | 23.54 | reference | |||
GA | 51.32 | 52.52 | 1.43 (1.02,1.99) | 0.0374 | 1.52(1.06,2.19) | 0.0227 | |||
GG | 15.89 | 23.94 | 2.10 (1.37,3.22) | 0.0007 | 2.40 (1.51,3.81) | 0.0002 | |||
GG/GA | 67.22 | 76.46 | 1.58 (1.15,2.18) | 0.0045 | 1.72 (1.22,2.43) | 0.0020 | |||