Myriocin prevents left ventricle ceramide accrual and mitochondrial dysfunction with cigarette smoke. Mice were exposed to room air (Con) or cigarette smoke (CS) for 1 wk while receiving PBS (vehicle) or myriocin injections every other day. A: Ceramides were measured from left ventricle following treatment period (n = 6). B: Mitochondrial respiration was reduced with CS treatment in vehicle-injected animals (n = 6). *P <0.05 for CS vs all other treatments.