Figure 4From: Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration Myriocin prevents left ventricle ceramide accrual and mitochondrial dysfunction with cigarette smoke. Mice were exposed to room air (Con) or cigarette smoke (CS) for 1 wk while receiving PBS (vehicle) or myriocin injections every other day. A: Ceramides were measured from left ventricle following treatment period (n = 6). B: Mitochondrial respiration was reduced with CS treatment in vehicle-injected animals (n = 6). *P <0.05 for CS vs all other treatments.Back to article page