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Table 1 Baseline characteristics of study population in 10 trials

From: Effects of ACEI/ARB in hypertensive patients with type 2 diabetes mellitus: a meta-analysis of randomized controlled studies

Study/author Public year Country Age (year) Total (I/C)* Female (%) follow-up years Medications used (I/C)* BP (mmHg) I(SBP/DBP; C(SBP/DBP Reduction of BP (mmHg)#I(SBP/DBP; C(SBP/DBP)
UKPDS [19] 1998 United Kingdom 56 400/358 48 over 9 Captopril/Atenolol 159/94; 159/93 15/10; 16/12
FACET [11] 1998 United State 63 189/191 41 2.5-3.5 Fosinopril/Amlodipine 170/95; 171/94 19/8; 13/8
RENAAL [23] 2001 Multi-centers 60 751/762 37 3.4 Losartan/Placebo 152/82; 153/82 12/8; 11/8
CAPPP [12] 2001 Sweden/Finland 25–66 309/263 38 6.1 Captopril/Conventional drugs 164/97; 163/97 8/4; 10/5
IDNT [14, 17]& 2001/2003 Multi-centers 30-70 579/569 32 2.6 Irbesartan/Placebo 160/87; 158/87 20/10; 16/7
ADVANCE [13] 2007 Multi-centers 66 5,569/5,571 43 4.3 Perindopril/Placebo 145/81; 145/81 5.6/2.2#
CASE-J [21] 2010 Japan 64 1,011/1,077 44 3.3 Candesartan/Amlodipine 160/88; 160/88 ---
DEMAND [20] 2011 Italy/Slovenia ≥40 127/127 37 3.8 Delapril/Placebo 147/87; 147/88 11/6; 9/5
NHS [22] 2012 Japan 63 575/575 34 3.2 Valsartan/Amlodipine 145/82; 144/81 14/9; 13/8
  1. UKPDS = United Kingdom Prospective Diabetes Study Group, FACET = Fosinopril Versus Amlodipine Cardiovascular Events Randomized Trial, RENAAL = Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan, CAPPP = The Captopril Prevention Project, IDNT = Irbesartan Diabetic Nephropathy Trial, ADVANCE = The Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation, CASE-J = candesartan antihypertensive survival evaluation in Japan, DEMAND = Delapril and Manidipine for Nephroprotection in Diabetes, NHS = NAGOYA HEART Study.
  2. *I/C = Intervention/Control, SBP = systolic blood pressure, DBP = diastolic blood pressure; #reduction of SBP/DBP in intervention group compared with in placebo; ----- not give detail information; &IDNT data was used in two articles for the analysis of different endpoint events.