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Table 1 The influences of atorvastatin on blood lipid, hs-CRP and IL-6

From: Effect of atorvastatin on the expression of gamma-glutamyl transferase in aortic atherosclerotic plaques of apolipoprotein E–knockout mice

  Time ND HCD HCD + Ato
TC(mmo/L) 0 W 1.51 ± 0.24 1.42 ± 0.34 1.32 ± 0.28
  8 W 1.53 ± 0.17 22.31 ± 1.96* 23.08 ± 1.77*
  16 W 1.49 ± 0.09 26.58 ± 2.08* 20.01 ± 1.16#
TG(mmo/L) 0 W 1.07 ± 0.51 0.99 ± 1.04 1.11 ± 0.08
  8 W 1.03 ± 0.45 1.24 ± 1.29 1.31 ± 0.78
  16 W 1.05 ± 0.59 1.44 ± 1.28 1.38 ± 0.56
LDL(mmo/L) 0 W 0.97 ± 0.14 1.06 ± 0.27 1.01 ± 0.03
  8 W 1.05 ± 0.08 15.33 ± 1.17* 15.88 ± 2.34*
  16 W 0.98 ± 0.33 16.87 ± 1.24* 9.53 ± 1.87#
hs-CRP(mg/ml) 0 W 2.34 ± 0.13 2.29 ± 0.14 2.33 ± 0.13
  8 W 2.41 ± 0.15 6.58 ± 1.72* 6.71 ± 1.68*
  16 W 2.39 ± 0.15 11.83 ± 2.09* 7.75 ± 1.87#
IL-6(ng/ml) 0 W 0.17 ± 0.05 0.16 ± 0.04 0.17 ± 0.05
  8 W 0.18 ± 0.05 0.32 ± 0.15* 0.34 ± 0.14*
  16 W 0.17 ± 0.06 0.57 ± 0.21* 0.13 ± 0.08#
  1. Apolipoprotein E–knockout mice were treated with ND, HCD, or HCD plus atorvastatin, as described in the Methods section.TC: total cholesterol; TG: total triglyceride; LDL: low-density lipoprotein; HDL: high-density lipoprotein; hs-CRP: high-sensitivity C-reactive protein; IL-6: interleukin-6. ND: normal standard diet; HCD: high-cholesterol diet; Ato: atorvastatin, at 5 mg•kg−1•d−1. Values are means ± SD, n =15 for each group. *:P < 0.01 compared with ND group; #:P < 0.05 compared with HCD group.