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Table 1 The influences of atorvastatin on blood lipid, hs-CRP and IL-6

From: Effect of atorvastatin on the expression of gamma-glutamyl transferase in aortic atherosclerotic plaques of apolipoprotein E–knockout mice

 

Time

ND

HCD

HCD + Ato

TC(mmo/L)

0 W

1.51 ± 0.24

1.42 ± 0.34

1.32 ± 0.28

 

8 W

1.53 ± 0.17

22.31 ± 1.96*

23.08 ± 1.77*

 

16 W

1.49 ± 0.09

26.58 ± 2.08*

20.01 ± 1.16#

TG(mmo/L)

0 W

1.07 ± 0.51

0.99 ± 1.04

1.11 ± 0.08

 

8 W

1.03 ± 0.45

1.24 ± 1.29

1.31 ± 0.78

 

16 W

1.05 ± 0.59

1.44 ± 1.28

1.38 ± 0.56

LDL(mmo/L)

0 W

0.97 ± 0.14

1.06 ± 0.27

1.01 ± 0.03

 

8 W

1.05 ± 0.08

15.33 ± 1.17*

15.88 ± 2.34*

 

16 W

0.98 ± 0.33

16.87 ± 1.24*

9.53 ± 1.87#

hs-CRP(mg/ml)

0 W

2.34 ± 0.13

2.29 ± 0.14

2.33 ± 0.13

 

8 W

2.41 ± 0.15

6.58 ± 1.72*

6.71 ± 1.68*

 

16 W

2.39 ± 0.15

11.83 ± 2.09*

7.75 ± 1.87#

IL-6(ng/ml)

0 W

0.17 ± 0.05

0.16 ± 0.04

0.17 ± 0.05

 

8 W

0.18 ± 0.05

0.32 ± 0.15*

0.34 ± 0.14*

 

16 W

0.17 ± 0.06

0.57 ± 0.21*

0.13 ± 0.08#

  1. Apolipoprotein E–knockout mice were treated with ND, HCD, or HCD plus atorvastatin, as described in the Methods section.TC: total cholesterol; TG: total triglyceride; LDL: low-density lipoprotein; HDL: high-density lipoprotein; hs-CRP: high-sensitivity C-reactive protein; IL-6: interleukin-6. ND: normal standard diet; HCD: high-cholesterol diet; Ato: atorvastatin, at 5 mg•kg−1•d−1. Values are means ± SD, n =15 for each group. *:P < 0.01 compared with ND group; #:P < 0.05 compared with HCD group.