Impact of psychosocial factors on cardiovascular morbimortality: a prospective cohort study

Table 3 Adjusted hazard ratios for cardiovascular events according to psychosocial factors stratified by gender

	Composite primary cardiovascular event		Myocardial infarction		Stroke		Cardiovascular death
	Adjusted HR (95% CI)^†‡	p-value	Adjusted HR (95% CI)^†‡	p-value	Adjusted HR (95% CI)^†‡	p-value	Adjusted HR (95% CI)^†‡	p-value
Men
Educational level*
High education	1.00 (ref)		1.00 (ref)		1.00 (ref)		1.00 (ref)
Low education	1.25 (0.87–1.80)	0.223	1.34 (0.76–2.35)	0.308	2.11 (1.09–4.06)	0.026	0.65 (0.36–1.16)	0.148
Social support in the household
Live with others	1.00 (ref)		1.00 (ref)		1.00 (ref)		1.00 (ref)
Live alone	0.74 (0.30–1.61)	0.512	0.74 (0.18–3.05)	0.682	0.33 (0.46–2.39)	0.272	1.53 (0.47–4.98)	0.477
Diagnosis of Depression
No	1.00 (ref)		1.00 (ref)		1.00 (ref)		1.00 (ref)
Yes	0.76 (0.40–1.46)	0.414	0.50 (0.16–1.60)	0.241	0.56 (0.17–1.79)	0.327	1.42 (0.56–3.62)	0.460
Women
Educational level*
High education	1.00 (ref)		1.00 (ref)		1.00 (ref)		1.00 (ref)
Low education	0.97 (0.56–1.70)	0.922	0.63 (0.27–1.50)	0.295	1.46 (0.62–3.43)	0.383	0.56 (0.22–1.39)	0.211
Social support in the household
Live with others	1.00 (ref)		1.00 (ref)		1.00 (ref)		1.00 (ref)
Live alone	0.81 (0.48–1.37)	0.437	1.12 (0.45–2.79)	0.810	0.54 (0.25–1.16)	0.114	1.04 (0.43–2.54)	0.926
Diagnosis of Depression
No	1.00 (ref)		1.00 (ref)		1.00 (ref)		1.00 (ref)
Yes	0.76 (0.48–1.22)	0.256	1.19 (0.57–2.48)	0.650	0.71 (0.38–1.33)	0.281	0.71 (0.27–1.88)	0.495

*High education means university studies or secondary school; Low education: up to primary studies.
^†Multivariable models were adjusted by: age, smoking, alcohol consumption, body-mass index, hypertension, type 2 diabetes, dyslipidemia and family history of premature coronary heart disease, and type Mediterranean diet intervention.
^‡Global test of proportional-hazard assumption (p-value based on the scaled Schoenfeld residuals) men: Composite primary cardiovascular event model (0.172); Myocardial infarction model (0.723); Stroke model (0.260); Cardiovascular death model (0.369); women: Global test of proportional-hazard assumption (p-value based on the scaled Schoenfeld residuals) women: Composite primary cardiovascular event model (0.553); Myocardial infarction model (0.320); Stroke model (0.870); Cardiovascular death model (0.458).

ISSN: 1471-2261