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Table 3 Diagnostic accuracy of NT-proBNP alone and 'NT-proBNP or previous MI' algorithm*

From: Utility of NT-proBNP as a rule-out test for left ventricular dysfunction in very old people with limiting dyspnoea: the Newcastle 85+ Study

  Sensitivity % Specificity % PPV % NPV % % of people screened requiring echo Number of cases picked up per 100 screened Number of cases missed per 100 screened Number of false positives per 100 screened
Systolic dysfunction, any grade (LVEF≤50%)         
NT-pro BNP alone (refer for echocardiography if ≥400ng/l) 54.7 50.0 36.3 68.0 51.0 18.7 15.5 32.9
‘NT-proBNP or previous MI' algorithm (refer for echocardiography if prior MI or NT-pro BNP ≥400ng/l) 64.2 44.1 37.4 70.3 58.7 21.9 12.3 36.8
Moderate/severe systolic dysfunction (LVEF≤40%)         
NT-pro BNP alone (refer for echocardiography if ≥400ng/l) 84.6 51.4 13.8 97.3 51.0 7.1 1.3 44.5
‘NT-proBNP or previous MI' algorithm (refer for echocardiography if prior MI or NT-pro BNP ≥400ng/l) 84.6 43.7 12.1 96.9 58.7 7.1 1.3 51.6
Systolic dysfunction (any grade) OR isolated moderate/severe diastolic dysfunction         
NT-pro BNP alone (refer for echocardiography if ≥400ng/l) 60.2 58.3 62.5 56.0 51.0 32.3 21.3 19.4
‘NT-proBNP or previous MI' algorithm (refer for echocardiography if prior MI or NT-pro BNP ≥400ng/l) 67.5 51.4 61.5 57.8 58.7 36.1 17.4 22.6
Moderate/severe systolic dysfunction OR isolated moderate/severe diastolic dysfunction         
NT-pro BNP alone (refer for echocardiography if ≥400ng/l) 74.4 57.1 40.0 85.3 51.0 20.6 7.1 31.0
‘NT-proBNP or previous MI' algorithm (refer for echocardiography if prior MI or NT-pro BNP ≥400ng/l) 76.7 48.2 36.3 84.4 58.7 21.3 6.5 37.4
  1. Detailed legend: Diagnostic accuracy of 'NT-proBNP or previous MI' algorithm as rule-out test for LV dysfunction (types as specified); comparison with strategy using NT-proBNP alone.
  2. *Abbreviations: PPV positive predictive value, NPV negative predictive value.