Table 3 Diagnostic accuracy of NT-proBNP alone and 'NT-proBNP or previous MI' algorithm*
| Â | Sensitivity % | Specificity % | PPV % | NPV % | % of people screened requiring echo | Number of cases picked up per 100 screened | Number of cases missed per 100 screened | Number of false positives per 100 screened |
|---|---|---|---|---|---|---|---|---|
Systolic dysfunction, any grade (LVEF≤50%) |  |  |  |  |  |  |  |  |
NT-pro BNP alone (refer for echocardiography if ≥400ng/l) | 54.7 | 50.0 | 36.3 | 68.0 | 51.0 | 18.7 | 15.5 | 32.9 |
‘NT-proBNP or previous MI' algorithm (refer for echocardiography if prior MI or NT-pro BNP ≥400ng/l) | 64.2 | 44.1 | 37.4 | 70.3 | 58.7 | 21.9 | 12.3 | 36.8 |
Moderate/severe systolic dysfunction (LVEF≤40%) |  |  |  |  |  |  |  |  |
NT-pro BNP alone (refer for echocardiography if ≥400ng/l) | 84.6 | 51.4 | 13.8 | 97.3 | 51.0 | 7.1 | 1.3 | 44.5 |
‘NT-proBNP or previous MI' algorithm (refer for echocardiography if prior MI or NT-pro BNP ≥400ng/l) | 84.6 | 43.7 | 12.1 | 96.9 | 58.7 | 7.1 | 1.3 | 51.6 |
Systolic dysfunction (any grade) OR isolated moderate/severe diastolic dysfunction | Â | Â | Â | Â | Â | Â | Â | Â |
NT-pro BNP alone (refer for echocardiography if ≥400ng/l) | 60.2 | 58.3 | 62.5 | 56.0 | 51.0 | 32.3 | 21.3 | 19.4 |
‘NT-proBNP or previous MI' algorithm (refer for echocardiography if prior MI or NT-pro BNP ≥400ng/l) | 67.5 | 51.4 | 61.5 | 57.8 | 58.7 | 36.1 | 17.4 | 22.6 |
Moderate/severe systolic dysfunction OR isolated moderate/severe diastolic dysfunction | Â | Â | Â | Â | Â | Â | Â | Â |
NT-pro BNP alone (refer for echocardiography if ≥400ng/l) | 74.4 | 57.1 | 40.0 | 85.3 | 51.0 | 20.6 | 7.1 | 31.0 |
‘NT-proBNP or previous MI' algorithm (refer for echocardiography if prior MI or NT-pro BNP ≥400ng/l) | 76.7 | 48.2 | 36.3 | 84.4 | 58.7 | 21.3 | 6.5 | 37.4 |