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Table 2 Hazard ratios (HRs) for discontinuation of clopidogrel treatment

From: Clopidogrel discontinuation within the first year after coronary drug-eluting stent implantation: an observational study

Time following DES implantation HR (95% CI) Adjusted HR (95% CI)
MACE 0-3 months 2.48 (1.30-4.71) 2.06 (1.08-3.93)
  3-6 months 1.26 (0.68-2.33) 1.29 (0.70-2.41)
  6-12 months 1.26 (0.53-2.99) 1.29 (0.54-3.07)
Cardiac death 0-3 months 6.84 (3.06-15.3) 4.80 (2.13-10.8)
  3-6 months 1.95 (0.72-5.30) 1.85 (0.68-5.04)
  6-12 months 1.65 (0.42-6.46) 1.74 (0.45-6.78)
Myocardial infarction 0-3 months 2.05 (0.93-4.53) 1.84 (0.83-4.09)
  3-6 months 1.08 (0.51-2.28) 1.14 (0.54-2.43)
  6-12 months 1.09 (0.36-3.35) 1.09 (0.35-3.34)
Definite stent thrombosis 0-3 months - -
  3-6 months 6.04 (0.52-70.2) 7.14 (0.61-83.7)
  6-12 months - -
  1. MACE is a composite of cardiac death, myocardial infarction, and definite stent thrombosis.
  2. Abbreviations: HR hazard ratio, CI confidence interval.
  3. Hazard ratios were adjusted for age, gender, year of index PCI, PCI indication, comorbidity level (using Charlson Comorbidity Index scores), and time-varying use (calculated from the number of days exposed) of aspirin, other NSAIDs, and proton pump inhibitors.
  4. 0-3 months = day 1 through 91; 3 to 6 months = day 92 through 182; 6 to 12 months = day 183 through 365.