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Table 4 Biological processes of the predicted miRNA targets

From: Atrial fibrillation alters the microRNA expression profiles of the left atria of patients with mitral stenosis

GO process

Target genes

P-value

miR-1

GO:0003723: RNA binding

DDX5 SFRS9 HNRNPU TRA2B CPEB1 SFRS1 HNRNPA3 HNRNPK SFRS3

6.57E-05

GO:0006397: mRNA processing

ISY1 DDX5 SFRS9 DHX15 HNRNPU CPEB1 SFRS1 HNRNPA3 HNRNPK SFRS3

5.69E-03

miR-26a-5p

GO:0007179: transforming growth factor beta receptor signaling pathway

TGFBR2 MAP3K1 NLK

5.41E-04

GO:0051301: cell division

CCNE2 CCNE1 CDK6 CCND2

7.90E-03

miR-466

GO:0003700: transcription factor activity

ARNT2 GLI3 SMAD2 RUNX1T1 TCF7L2 MECOM

4.56E-04

GO:0005515: protein binding

CCDC6 KIT CYCS EIF4E COL4A1 PTGS2 RUNX1T1 ULK2 MECOM RICTOR

6.19E-04

GO:0006468: protein amino acid phosphorylation

PRKAA2 RPS6KA3 SMAD2 ULK2 DAPK1

9.15E-04

GO:0046872: metal ion binding

CYCS GLI3 PTGS2 RUNX1T1 MECOM

6.58E-03

miR-574-3p

GO:0031625: ubiquitin protein ligase binding

CUL2 ACVR1B

1.46E-03

GO:0051384: response to glucocorticoid stimulus

EP300 RXRA

3.87E-03

miR-3613-3p

GO:0003700: transcription factor activity

NFATC3 NFAT5 EP300 RARA CREBBP RUNX1T1 RUNX1 ETS1 TCF7L2 NKX3-1 HDAC2 STAT3 CTNNB1 SMAD4

5.59E-13

GO:0004842: ubiquitin-protein ligase activity

UBE2J1 UBE2H UBE2Z BIRC6 MAP3K1 UBE2N UBE2D3 UBE2B NEDD4L LMO7 UBE2R2 HUWE1 UBE2E2 UBE2G1

5.61E-06

GO:0006355: regulation of transcription, DNA dependent

NFAT5 EP300 RARA CREBBP ABL1 RUNX1T1 RUNX1 NKX3-1 CREB1

1.65E-03

GO:0008134: transcription factor binding

PPARGC1A ETS1 TCF7L2 NKX3-1 HDAC2 PIM1 STAT3 CTNNB1

6.19E-06

GO:0008284: positive regulation of cell proliferation

FGFR2 FGFR1 ADAM17 INSR KIT BIRC6 HDAC2 IGF1R CCND1 KRAS

8.74E-04

GO:0046872: metal ion binding

PRKCI EP300 ACACB RARA CREBBP RUNX1T1 MID1 ADAM17 INSR PPP1CB PIM1 XIAP EGLN1 IGF1R LMO7 TRAF3

4.16E-04

GO:0051246: regulation of protein metabolic process

UBE2J1 UBE2H UBE2Z BIRC6 UBE2N UBE2D3 UBE2B UBE2R2 UBE2E2 UBE2G1

5.24E-05