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Table 3 Uni- and multivariable predictors of the biomarkers dynamics (change from baseline to one-year)

From: Impact of percutaneous coronary intervention on biomarker levels in patients in the subacute phase following myocardial infarction: the Occluded Artery Trial (OAT) biomarker ancillary study

 

Univariable model

Multivariable model

Estimate

ProbChiSq

Estimate

ProbChiSq

NT-proBNP

Baseline NT-proBNP

-0.699

<.001

-0.695

<.001

 

PCI versus med

-6.939

0.979

-253.604

0.162

 

Famliy history of CAD

-511.007

0.052

-448.534

0.015

 

New Q waves

-531.444

0.067

-

-

VEGF

Baseline VEGF

-0.750

<.001

-0.727

<.001

 

PCI versus med

-42.952

0.109

-5.514

0.694

 

History of cerebrovascular disease

-108.966

0.065

-

-

 

Current smoker

-53.395

0.049

-

-

 

Thrombolytic therapy

220.645

0.026

171.550

<0.001

MMP-2

Baseline MMP-2

-0.982

<.001

-0.979

<.001

 

PCI versus med.

-51.316

0.351

-11.677

0.384

 

systolic blood pressure (10 mmHg)

40.239

0.079

-

-

 

diastolic blood pressure (10 mmHg)

62.034

0.053

-

-

MMP-9

Baseline MMP-9

-0.751

<.001

-0.742

<.001

 

PCI versus med.

-24.601

0.436

0.526

0.981

 

MI history

122.755

0.081

104.471

0.032

 

History of cerebrovascular disease

-185.871

0.006

-

-

 

Current smoker

-58.054

0.068

-

-

TIMP-2

Baseline TIMP-2

-0.919

<.001

-0.885

<.001

 

PCI versus med.

0.412

0.914

-2.558

0.255

 

Male versus Female

8.349

0.049

-

-

 

History of Renal Insufficiency

17.714

0.085

22.685

0.003

 

Family history of CAD

6.314

0.099

-

-

 

Current smoker

-7.321

0.056

-5.025

0.029

 

Heart rate (10 beats/minute)

3.213

0.099

3.566

0.002

 

BMI (10 kg/m2)

-9.403

0.087

-11.541

<0.001

GALECTIN

Baseline GALECTIN

-0.82

<.001

-0.77

<.001

 

PCI versus med.

-0.734

0.674

0.037

0.975

 

Angina history

-3.418

0.087

-

-

 

PCI history

6.348

0.059

-

-

 

Thrombolytic therapy

-13.353

0.040

-10.305

0.023

 

BMI (10 kg/m2)

8.281

<0.001

7.326

<.001

 

Ejection fraction (10%)

-1.983

0.018

-

-

  1. NT-proBNP- N-terminal prohormone of brain natriuretic peptide, matrix metalloproteinase-MMP, tissue inhibitor of matrix metalloproteinases- TIMP, Vascular Endothelial Growth Factor -VEGF.
  2. BMI-body mass index, CAD-coronary artery disease, MED-medical therapy, MMP-matrix metalloproteinase; NT-proBNP- N-terminal prohormone of brain natriuretic peptide; PCI-percutaneous coronary intervention; TIMP - tissue inhibitor of matrix metalloproteinase; VEGF-Vascular Endothelial Growth Factor.
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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