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Table 3 Uni- and multivariable predictors of the biomarkers dynamics (change from baseline to one-year)

From: Impact of percutaneous coronary intervention on biomarker levels in patients in the subacute phase following myocardial infarction: the Occluded Artery Trial (OAT) biomarker ancillary study

  Univariable model Multivariable model
Estimate ProbChiSq Estimate ProbChiSq
NT-proBNP Baseline NT-proBNP -0.699 <.001 -0.695 <.001
  PCI versus med -6.939 0.979 -253.604 0.162
  Famliy history of CAD -511.007 0.052 -448.534 0.015
  New Q waves -531.444 0.067 - -
VEGF Baseline VEGF -0.750 <.001 -0.727 <.001
  PCI versus med -42.952 0.109 -5.514 0.694
  History of cerebrovascular disease -108.966 0.065 - -
  Current smoker -53.395 0.049 - -
  Thrombolytic therapy 220.645 0.026 171.550 <0.001
MMP-2 Baseline MMP-2 -0.982 <.001 -0.979 <.001
  PCI versus med. -51.316 0.351 -11.677 0.384
  systolic blood pressure (10 mmHg) 40.239 0.079 - -
  diastolic blood pressure (10 mmHg) 62.034 0.053 - -
MMP-9 Baseline MMP-9 -0.751 <.001 -0.742 <.001
  PCI versus med. -24.601 0.436 0.526 0.981
  MI history 122.755 0.081 104.471 0.032
  History of cerebrovascular disease -185.871 0.006 - -
  Current smoker -58.054 0.068 - -
TIMP-2 Baseline TIMP-2 -0.919 <.001 -0.885 <.001
  PCI versus med. 0.412 0.914 -2.558 0.255
  Male versus Female 8.349 0.049 - -
  History of Renal Insufficiency 17.714 0.085 22.685 0.003
  Family history of CAD 6.314 0.099 - -
  Current smoker -7.321 0.056 -5.025 0.029
  Heart rate (10 beats/minute) 3.213 0.099 3.566 0.002
  BMI (10 kg/m2) -9.403 0.087 -11.541 <0.001
GALECTIN Baseline GALECTIN -0.82 <.001 -0.77 <.001
  PCI versus med. -0.734 0.674 0.037 0.975
  Angina history -3.418 0.087 - -
  PCI history 6.348 0.059 - -
  Thrombolytic therapy -13.353 0.040 -10.305 0.023
  BMI (10 kg/m2) 8.281 <0.001 7.326 <.001
  Ejection fraction (10%) -1.983 0.018 - -
  1. NT-proBNP- N-terminal prohormone of brain natriuretic peptide, matrix metalloproteinase-MMP, tissue inhibitor of matrix metalloproteinases- TIMP, Vascular Endothelial Growth Factor -VEGF.
  2. BMI-body mass index, CAD-coronary artery disease, MED-medical therapy, MMP-matrix metalloproteinase; NT-proBNP- N-terminal prohormone of brain natriuretic peptide; PCI-percutaneous coronary intervention; TIMP - tissue inhibitor of matrix metalloproteinase; VEGF-Vascular Endothelial Growth Factor.
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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