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Figure 1 | BMC Cardiovascular Disorders

Figure 1

From: The role of the Hsp90/Akt pathway in myocardial calpain-induced caspase-3 activation and apoptosis during sepsis

Figure 1

Panel A, The time course of myocardial Hsp90/p-Akt (Thy308) protein expression. Hsp90 and p-Akt/Akt protein expression was determined by Western blot at 0, 1, 2, 4, and 6 h after LPS (4 mg/kg) treatment. Panel B, Myocardial Hsp90/p-Akt expression is decreased in septic mice. In the mice were treated with LPS (4 mg/kg, i.p.) for 4 h, the myocardial Hsp90/p-Akt expression was detected. Panel C, Myocardial caspase-3 activity in the septic mice. Mice were treated with LPS (4 mg/kg, i.p.) for 4 h, the heart tissues were extracted and caspase-3 activity was determined. The data are shown as the mean ± SE (n = 5). LPS, lipopolysaccharide; CI, calpain inhibitor-III., PD, PD150606. * vs. sham, P < 0.05; # vs. LPS, P < 0.05.

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