Use of a highly-sensitive cardiac troponin I assay in a screening population for hypertrophic cardiomyopathy: a case-referent study

Table 4 Association of both standard and highly sensitive cardiac troponin I assays with an echo diagnosis of definite HCM, using logistic regression analysis

		Odds ratio (95% CI)	P value	Pseudo R2	AUROC (95% CI)
*cTnI models*
Model 1*	Natural log of cTnI	4.20 (0.94, 18.80)	0.060	0.102	0.66 (0.51, 0.82)
Model 2 **	Natural log of cTnI	2.56 (0.54, 12.14)	0.236	0.197	0.76 (0.62, 0.91)
*hsTnI models*
Model 1*	Natural log of hsTnI	2.35 (1.39, 3.96)	0.001	0.173	0.78 (0.65, 0.90)
Model 2 **		1.82 (1.02, 3.24)	0.042	0.231	0.81 (0.70, 0.93)

* Model 1 adjusted for age and sex.
** Model 2 adjusted for age, sex, presence of group 2 ECG abnormalities, and symptoms of dyspnoea, chest pain, syncope or palpitations.
Footnote: For the ln(cTnI): comparison between AUROC in Model 1 vs Model 2: χ2=1.90, p=0.168. For the ln(hsTnI): comparison between AUROC in Model 1 vs Model 2: χ2=1.03, p=0.310. For the comparison between the AUROCs in Model 2 for the models with ln(cTnI) and ln(hsTnI): χ2= 0.87, p=0.351.

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