Table 2 Echocardiographic characteristics of the study population, stratified by standard echo criteria for HCM 1,3
Normal screening echo (n = 64) | Borderline HCM (n = 24) | Definite HCM (n = 19) | Test statistic* | P-value | |
|---|---|---|---|---|---|
2D-TM Data: mean [SD] | |||||
IVSd (mm) | 10.30 (2.17) | 12.38 (2.36) | 15.53 (4.50) | F= 27.33 | <0.0001 |
LVPWd (mm) | 9.22 (1.67) | 11.00 (2.57) | 11.32 (2.31) | F=11.79 | <0.0001 |
IVS/LVPW ratio | 1.13 (0.20) | 1.17 (0.33) | 1.38 (0.33) | F=6.77 | 0.0017 |
LVIDd (mm) | 48.86 (5.76) | 50.42 (6.00) | 47.16 (7.92) | F= 1.45 | 0.239 |
LA diameter (mm) | 34.75 (5.62) | 38.98 (4.02) | 36.72 (4.96) | F= 5.73 | 0.0044 |
LVEF M Mode (%) | 61.81 (7.08) | 66.17 (7.46) | 68.33 (11.82) | F=5.67 | 0.0046 |
LVOT gradient (mmHg) | 5.32 (1.87) | 5.91 (2.39) | 7.00 (3.27) | F=3.35 | 0.0399 |
RWT (mm) | 0.38 (0.06) | 0.44 (0.07) | 0.50 (0.08) | F=26.78 | <0.0001 |
MWT (mm) | 10.62 (1.13) | 13.42 (0.50) | 17.63 (3.65) | F= 118.46 | <0.0001 |
Maximal LV wall dimensions in diastole: | |||||
Antero- septal wall (mm) | 10.12 (1.37) | 12.58 (1.10) | 16.63 (3.39) | F=93.87 | <0.0001 |
Postero- septal wall (mm) | 9.88 (1.32) | 12.67 (1.27) | 15.84 (4.57) | F=55.64 | <0.0001 |
Antero-lateral wall (mm) | 9.22 (1.13) | 10.83 (1.61) | 11.53 (2.09) | F=23.74 | <0.0001 |
Posterior wall (mm) | 9.25 (1.09) | 10.96 (1.08) | 11.68 (2.03) | F=32.74 | <0.0001 |
LV Mass (g) | 172.55 (48.34) | 230.29 (60.66) | 268.53 (133.37) | F=14.96 | <0.0001 |
Pulsed Doppler | |||||
Peak E velocity (cm/s) | 0.80 (0.17) | 0.73 (0.22) | 0.79 (0.14) | F=1.60 | 0.206 |
Peak A velocity (cm/s) | 0.58 (0.17) | 0.58 (0.13) | 0.60 (0.18) | F=0.16 | 0.854 |
E/A ratio | 1.49 (0.49) | 1.31 (0.51) | 1.45 (0.61) | F=0.98 | 0.379 |
E deceleration time (ms) | 187.87 (60.29) | 203.50 (33.91) | 220.11 (61.30) | F=2.60 | 0.079 |
Tissue Doppler | |||||
Septal Sa (cm/s) | 8.25 (2.35) | 7.68 (2.48) | 7.10 (1.99) | F=1.54 | 0.220 |
Septal Ea (cm/s) | 10.22 (3.33) | 7.01 (3.29) | 7.90 (3.90) | F=8.02 | 0.0006 |
Septal Aa (cm/s) | 8.89 (2.11) | 8.96 (3.58) | 8.09 (2.64) | F=0.60 | 0.550 |
Lateral Sa (cm/s) | 10.13 (3.38) | 8.41 (3.14) | 8.29 (2.44) | F=3.18 | 0.047 |
Lateral Ea (cm/s) | 12.87 (5.99) | 9.95 (4.03) | 11.19 (4.27) | F=2.52 | 0.087 |
Lateral Aa (cm/s) | 8.85 (2.99) | 7.87 (3.39) | 7.78 (3.50) | F=1.06 | 0.350 |
Echocardiograph composite scores | |||||
Adjusted 2D-LVH score | 36.28 (2.69) | 39.71 (2.69) | 39.03 (2.80) | F=12.33 | <0.0001 |
Spirito index (mm) | 38.47 (3.71) | 47.04 (3.03) | 55.68 (9.53) | F=90.81 | <0.0001 |
Gandjbakhch risk score | −2.78 (1.59) | −0.95(3.77) | 0.57 (2.59) | F=11.91 | <0.0001 |