Table 1 Variables and instruments
Variables | Instruments |
|---|---|
Cardiovascular | |
Coronary, carotid, and thoracic aorta calcium scores | 64-slice dual-source MDCT scanner |
CIMT and carotid plaque burden | Bilateral carotid artery ultrasound imaging (mm) |
ECG-derived - time domain analysis, frequency domain analysis, heart rate turbulence | 24-hour Holter monitor |
LV structure, LV systolic/diastolic function, valve function | Echocardiography |
Heart rate | Echocardiogram |
Aortic compliance- pulse wave analysis, pulse wave velocity | SphygmoCor (AtCor Medical, Sydney, Australia) |
Cardiovascular history | Charleston comorbidity Index (17 items) |
Blood pressure | 3 times right and left arms |
Ankle brachial index | Pocket fetal doppler Sonoline B |
(Clinical Guard, Atlanta, GA) | |
6-minute walk test | Marked distance totaled |
Emotional status | |
DSM IV diagnosis: current and lifetime major unipolar depression, generalized anxiety and panic disorder | DISH (38 items) |
Hamilton rating scale: severity of current depression | |
Psychiatric history | |
Screen for all exclusionary psychiatric conditions | |
Stressful/traumatic life events | LEC (1–15 events) |
Depression | CES-D (11 items;≥9 points indicates clinically-relevant number of depressive symptoms) |
Current clinical covariates | |
Fruit and vegetable consumption | CDC questionnaire (6 items) |
Medication use | Self-report |
Tobacco and alcohol use | Self-report |
Anthropometrics- height, weight, waist/hip | Trained research members |
Physical activity | IPAQ-short (9 items) |
Laboratory & biomarker assays | |
BMP, fasting glucose, fasting lipid profile, and HgbA1C | Fasting blood draw |
CRP, TNF-α, TNFR1, TNFR2, IL-6, TGF-β, VCAM, ICAM, MMP-9 | Panomics multiplex immunoassay |
(Affymetrix, Santa Clara, CA) | |
Built environment | |
Neighborhood of residence location | Questionnaire re: location; geographic information system analyses and in-person assessments as part of parent AAH study (2010) |