Cytochrome P450 2C19*2 polymorphism in patients with stable coronary heart disease and risk for secondary cardiovascular disease events: results of a long-term follow-up study in routine clinical care

Table 5 **Measures of model accuracy with and without CYP2C19C*2 status information (n=1050)**

	Basic model*	Basic model plus CYP2C19 polymorphism
Model fit
LR	69.25 (df=15, p<0.0001)	69.80 (df=16, p<0.0001)
AIC	1603.8	1605.2
BIC	1646.1	1650.3
Discrimination
C-statistic (AUC, 95% CI)	0.693 (0.645-0.742)	0.695 (0.647-0.744)
Calibration
Integrated discrimination improvement (IDI)		0.00016 (p=0.87)
Net reclassification improvement (NRI)		−1.3% (p=0.60)

* adjusted for age, gender, BMI, school education, , rehabilitation clinic, smoking status, history of diabetes mellitus, PCI, CABG, left ventricular function, HDL-cholesterol, LDL-cholesterol, treatment with lipid-lowering drugs, NT-proBNP [pg/mL].

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