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Table 2 CYP2C19C*2 allele status according to various sociodemographic characteristics, cardiovascular risk factors, and ECG findings at baseline

From: Cytochrome P450 2C19*2 polymorphism in patients with stable coronary heart disease and risk for secondary cardiovascular disease events: results of a long-term follow-up study in routine clinical care

   N CYP2C19C*2 allele status (row%) (AG or AA) p-value CYP2C19C*2 allele status (row%) (AA only) p-value*
All   1050     
Gender - Female 158 26.6   1.9  
- Male 892 29.6 0.44 2.7 0.75
Age (years) - 30-39 23 47.8   8.7  
- 40-49 133 21.1   1.5  
- 50-59 304 30.3   2.6  
- 60-70 590 29.7 0.04 2.5 0.10
School education - < 10 yrs. 625 31.2   3.8  
- ≥ 10 yrs. 425 26.1 0.08 1.8 0.008
Body mass index (kg/m2) - < 25 299 26.4   3.0  
- 25-30 560 30.7   3.0  
- >30 190 28.4 0.41 0.5 0.18
Smoking status - Never 333 28.8   1.2  
- Ex 664 29.2   3.2  
- Current 53 30.2 0.98 3.8 0.34
History of diabetes - Yes 184 28.8   2.7  
- No 866 29.2 0.91 2.5 0.94
History of MI - Yes 611 30.9   2.6  
- No 439 26.7 0.13 2.5 0.31
History of hypertension - Yes 583 29.5   2.7  
- No 467 28.7 0.77 2.4 0.92
History of heart failure - Yes 128 25.0   2.3  
- No 891 29.6 0.28 2.6 0.58
Angiographic score (number of affected vessels) - Zero/one 270 28.2   1.1  
- Two 279 30.5   3.6  
- Three 449 29.4 0.84 2.7 0.46
Initial management of CHD - Conservative 193 25.4   1.6  
- PCI 361 28.8   2.8  
- CABG 496 30.9 0.36 2.8 0.68
Left ventricular function* (degree of impairment) - No/only little 746 28.7   2.6  
- Modest/severe 217 29.5   3.2  
- Unknown 87 32.2 0.79 1.2 0.79
Lipid-lowering agent - Yes 810 28.9   2.6  
- No 238 29.8 0.78 2.5 0.96
Beta-blocker - Yes 916 28.9   2.5  
- No 132 30.3 0.75 3.0 0.87
Calcium antagonist - Yes 86 27.9   3.5  
- No 962 29.2 0.80 2.5 0.67
ACE inhibitor - Yes 557 28.4   2.5  
- No 491 29.9 0.58 2.7 0.86
Diuretic - Yes 255 31.0   2.4  
- No 793 28.5 0.45 2.7 0.68
ASA - Yes 915 29.0   2.7  
- No 133 30.1 0.79 1.5 0.69
Clopidogrel or Ticlopidine - Yes 87 33.3   2.3  
- No 963 28.8 0.37 2.6 0.59
Proton Pump Iinhibitor (PPI) - Yes 66 33.3   0.0  
- No 984 28.9 0.44 2.7 0. 25
Clopidogrel or Ticlopidine or PPI - Yes 141 34.0   1.4  
- No 909 28.4 0.17 2.8 0.18
  1. *=Fishers Exact Test.
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