Beta-blockers for the prevention of sudden cardiac death in heart failure patients: a meta-analysis of randomized controlled trials

Table 1 Randomized trials of beta blockers for the prevention of sudden cardiac death

Trial (Reference)	Year	Number of patients	Name of drug	Comparator	Daily maintenance dose (mg)	Follow-up (months)	Jadad scoring
Anderson et al.¹²	1985	50	Metoprolol	Control	61	19	3
ANZ¹⁶	1997	415	Carvedilol	Placebo	12.5	19	4
BEST⁶	2001	2708	Bucindolol	Placebo	152	24	5
BHAT³⁹	1986	3837	Propranolol	Placebo	180/240	25	5
Bristow et al.¹⁷	1994	139	Bucindolol	Placebo	12.5/50/200	3	5
Bristow et al.¹⁸	1996	345	Carvedilol	Placebo	12.5/25/50	6	5
Capricorn¹⁹	2001	1959	Carvedilol	Placebo	50	15.6	5
CIBIS II²¹	1999	2647	Bisoprolol	Placebo	10	15	5
CIBIS²⁰	1994	641	Bisoprolol	Placebo	5	23	5
CILICARD³³	2000	124	Celiprolol	Placebo	100	12	5
Colucci et al.²²	1996	366	Carvedilol	Placebo	100	15	5
COPERNICUS⁸	2002	2289	Carvedilol	Placebo	50	10.4	5
De Milliano et al.³⁴	2002	59	Metoprolol	Placebo	150	6	5
ELANDD³⁵	2011	116	Nebivelol	Placebo	5/10	6	5
Engleimeir et al.²³	1985	25	Metoprolol	Placebo	92	12	4
Fisher et al.²⁴	1994	50	Metoprolol	Placebo	87	6	5
Hansteen V. et al.²⁵	1982	560	Propranolol	Placebo	160	12	5
Krum et al.²⁶	1995	49	Carvedilol	Placebo	50	4	5
MDC²⁷	1993	383	Metoprolol	Placebo	108/115	18	3
MERIT-HF²⁸	1999	3991	Metoprolol	Placebo	159/170	12	5
Metra et al.²⁹	1994	40	Carvedilol	Placebo	50	4	4
Olsen et al.³⁰	1995	60	Carvedilol	Placebo	81	4	5
Packer et al.³¹	1996	1094	Carvedilol	Placebo	60	6	5
Pollock et al.³²	1990	19	Bucindolol	Placebo	200	3	4
RESOLVD³⁶	2000	426	Metoprolol	Placebo	156	6	5
SENIORS¹⁴	2005	2128	Nebivelol	Placebo	7.7	21	5
Sturm³⁷	2000	100	Atenolol	Placebo	89	24	5
UHLIR et al.^38a	1997	91	Nebivelol	Placebo	2.5/5	3.5	5
Wisenbaugh et al.¹⁵	1993	24	Nebivelol	placebo	5	3	5
Woodley et al.¹³	1991	50	Bucindolol	Placebo	175	3	5

ANZ: Australian/New Zealand Heart Failure Research Collaborative Group; BEST: Beta-blocker Bucindolol in patients with advanced chronic heart failure; CAPRICORN: Effect of carvedilol on outcome after myocardial infarction inpatients; COPRINCUS: Effect of Carvedilol on the Morbidity of Patients with Severe chronic Heart Failure; MDC: Metoprolol in Dilated Cardiomyopathy Trial study; Merit-HF: Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure; SENIORS: Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure.

ISSN: 1471-2261