WT | Ob/ob | DKO | |||||
---|---|---|---|---|---|---|---|
At 12 w | Untreated | Food restriction | ACE-I | Untreated | Food restriction | ACE-I | |
Body Weight(g) | 21.1±1.0 | 49.5±0.6* | 49.8±0.9* | 49.0±0.3* | 48.8±0.7* | 51.2±0.6* | 45.2±1.6* |
Glycemia(mg/dL) | 56±2.0 | 159.3±18.5* | 166±13.7* | 155±14.5* | 155±10.2* | 156±8.8* | 160±12.9* |
Total Chol(mg/dL) | 104±25 | 129±6£ | 131±6 | 116±6 | 977±45*+ | 958±77* | 735±90*£ |
Triglycerides(mg/dL) | 115±15 | 53±2*£ | 53±2* | 69±3* | 585±66*+ | 618±75* | 455±69* |
HDL(mg/dL) | 68±11 | 106±5*£ | 107±5* | 90±4* | 232±5*+ | 112±10*£ | 137±11*£ |
LDL(mg/dL) | 16±11 | 13±2 | 14±2 | 12±3 | / | / | 308±228* |
WT | Ob/ob | DKO | |||||
At 18 w | Untreated | Food restriction | ACE-I | Untreated | Food restriction | ACE-I | |
Body Weight(g) | 22.1±1.3 | 56.6±0.9*£ | 37.1±1.1*+ | 54.0±0.4* | 49.8±3.4*+ | 37.3±0.7*£ | 53.9±1.8* |
Glycemia(mg/dL) | 72±4.5 | 134±18.9 | 176±19.9* | 119±9.1 | 142±13.4 | 158±19.8* | 191±24.3* |
Total Chol(mg/dL) | 80±7 | 154±13* | 77±6+ | 140±10* | 579±145*+ | 794±59* | 527±63* |
Triglycerides(mg/dL) | 75±6 | 81±2 | 74±5 | 70±2 | 334±80*+ | 331±38* | 171±19£ |
HDL(mg/dL) | 62±6 | 123±9*£ | 67±7+ | 112±7* | 100±6*+ | 201±18*£ | 159±11*£ |
LDL(mg/dL) | 4±2 | 15±4* | / | 16±3* | 277±100*+ | 519±35*£ | 334±50* |
WT | Ob/ob | DKO | |||||
At 24 w | Untreated | Food restriction | ACE-I | Untreated | Food restriction | ACE-I | |
Body Weight(g) | 27.1±0.9 | 64.5±0.9* | 34.0±2.3*+ | 65.8±1.3* | 61.2±1.7* | 35.9±1.3*£ | 61.8±1.0* |
Heart Weight(mg) | 164.4±9.6 | 196.1±9.3* | 136.4±2.8*+ | 178.7±4.0 | 184.2±10.0 | 132.7±3.0*£ | 161.2±4.0£ |
HW/BW ratio(mg/g) | 6.2±0.5 | 3.1±0.1* | 4.3±0.3*+ | 2.7±0.1* | 3.1±0.1* | 3.8±0.2* | 2.6±0.1* |
Glycemia(mg/dL) | 71±4,5 | 166±11.8* | 142±12.1* | 84±5.0+ | 141±28.6* | 153±18.2* | 124±8.7* |
Total Chol(mg/dL) | 93±17 | 139±10 | 74±8 | 145±10 | 576±78*+ | 816±74*£ | 634±55* |
Triglycerides(mg/dL) | 68±9 | 68±3 | 69±5 | 76±4 | 210±30*+ | 301±60* | 202±21* |
HDL(mg/dL) | 73±9 | 97±6 | 66±8 | 100±2 | 183±15*+ | 232±21*£ | 192±4* |
LDL(mg/dL) | 8±7 | 29±5 | / | 34±8 | 351±66*+ | 432±24* | 402±49* |