Skip to main content

Table 1 Metabolic and phenotypic evolution

From: ACE-inhibition, but not weight reduction restores cardiomyocyte response to β-adrenergic stimulation in the metabolic syndrome

  WT Ob/ob DKO
At 12 w   Untreated Food restriction ACE-I Untreated Food restriction ACE-I
Body Weight(g) 21.1±1.0 49.5±0.6* 49.8±0.9* 49.0±0.3* 48.8±0.7* 51.2±0.6* 45.2±1.6*
Glycemia(mg/dL) 56±2.0 159.3±18.5* 166±13.7* 155±14.5* 155±10.2* 156±8.8* 160±12.9*
Total Chol(mg/dL) 104±25 129±6£ 131±6 116±6 977±45*+ 958±77* 735±90*£
Triglycerides(mg/dL) 115±15 53±2*£ 53±2* 69±3* 585±66*+ 618±75* 455±69*
HDL(mg/dL) 68±11 106±5*£ 107±5* 90±4* 232±5*+ 112±10*£ 137±11*£
LDL(mg/dL) 16±11 13±2 14±2 12±3 / / 308±228*
  WT Ob/ob DKO
At 18 w   Untreated Food restriction ACE-I Untreated Food restriction ACE-I
Body Weight(g) 22.1±1.3 56.6±0.9 37.1±1.1*+ 54.0±0.4* 49.8±3.4*+ 37.3±0.7*£ 53.9±1.8*
Glycemia(mg/dL) 72±4.5 134±18.9 176±19.9* 119±9.1 142±13.4 158±19.8* 191±24.3*
Total Chol(mg/dL) 80±7 154±13* 77±6+ 140±10* 579±145*+ 794±59* 527±63*
Triglycerides(mg/dL) 75±6 81±2 74±5 70±2 334±80*+ 331±38* 171±19£
HDL(mg/dL) 62±6 123±9 67±7+ 112±7* 100±6*+ 201±18*£ 159±11*£
LDL(mg/dL) 4±2 15±4* / 16±3* 277±100*+ 519±35*£ 334±50*
  WT Ob/ob DKO
At 24 w   Untreated Food restriction ACE-I Untreated Food restriction ACE-I
Body Weight(g) 27.1±0.9 64.5±0.9* 34.0±2.3*+ 65.8±1.3* 61.2±1.7* 35.9±1.3*£ 61.8±1.0*
Heart Weight(mg) 164.4±9.6 196.1±9.3* 136.4±2.8*+ 178.7±4.0 184.2±10.0 132.7±3.0*£ 161.2±4.0£
HW/BW ratio(mg/g) 6.2±0.5 3.1±0.1* 4.3±0.3*+ 2.7±0.1* 3.1±0.1* 3.8±0.2* 2.6±0.1*
Glycemia(mg/dL) 71±4,5 166±11.8* 142±12.1* 84±5.0+ 141±28.6* 153±18.2* 124±8.7*
Total Chol(mg/dL) 93±17 139±10 74±8 145±10 576±78*+ 816±74*£ 634±55*
Triglycerides(mg/dL) 68±9 68±3 69±5 76±4 210±30*+ 301±60* 202±21*
HDL(mg/dL) 73±9 97±6 66±8 100±2 183±15*+ 232±21*£ 192±4*
LDL(mg/dL) 8±7 29±5 / 34±8 351±66*+ 432±24* 402±49*
  1. This table shows the metabolic and phenotypic evolution from 12 till 24 weeks of age of WT (N =13), untreated ob/ob (N =10), untreated DKO (N =13), food-restricted ob/ob (N =32), food-restricted DKO (N =19), ob/ob treated with ACE-I (N =14) and DKO treated with ACE-I (N =16).
  2. * denotes p < 0.05 vs. WT, + p < 0.05 vs. untreated ob/ob and £ p < 0.05 vs. untreated DKO; HW heart weight, BW body weight, Total Chol total cholesterol, HDL high-density lipoprotein, LDL low-density lipoprotein and / = No data available.