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Table 1 Metabolic and phenotypic evolution

From: ACE-inhibition, but not weight reduction restores cardiomyocyte response to β-adrenergic stimulation in the metabolic syndrome

 

WT

Ob/ob

DKO

At 12 w

 

Untreated

Food restriction

ACE-I

Untreated

Food restriction

ACE-I

Body Weight(g)

21.1±1.0

49.5±0.6*

49.8±0.9*

49.0±0.3*

48.8±0.7*

51.2±0.6*

45.2±1.6*

Glycemia(mg/dL)

56±2.0

159.3±18.5*

166±13.7*

155±14.5*

155±10.2*

156±8.8*

160±12.9*

Total Chol(mg/dL)

104±25

129±6£

131±6

116±6

977±45*+

958±77*

735±90*£

Triglycerides(mg/dL)

115±15

53±2*£

53±2*

69±3*

585±66*+

618±75*

455±69*

HDL(mg/dL)

68±11

106±5*£

107±5*

90±4*

232±5*+

112±10*£

137±11*£

LDL(mg/dL)

16±11

13±2

14±2

12±3

/

/

308±228*

 

WT

Ob/ob

DKO

At 18 w

 

Untreated

Food restriction

ACE-I

Untreated

Food restriction

ACE-I

Body Weight(g)

22.1±1.3

56.6±0.9

37.1±1.1*+

54.0±0.4*

49.8±3.4*+

37.3±0.7*£

53.9±1.8*

Glycemia(mg/dL)

72±4.5

134±18.9

176±19.9*

119±9.1

142±13.4

158±19.8*

191±24.3*

Total Chol(mg/dL)

80±7

154±13*

77±6+

140±10*

579±145*+

794±59*

527±63*

Triglycerides(mg/dL)

75±6

81±2

74±5

70±2

334±80*+

331±38*

171±19£

HDL(mg/dL)

62±6

123±9

67±7+

112±7*

100±6*+

201±18*£

159±11*£

LDL(mg/dL)

4±2

15±4*

/

16±3*

277±100*+

519±35*£

334±50*

 

WT

Ob/ob

DKO

At 24 w

 

Untreated

Food restriction

ACE-I

Untreated

Food restriction

ACE-I

Body Weight(g)

27.1±0.9

64.5±0.9*

34.0±2.3*+

65.8±1.3*

61.2±1.7*

35.9±1.3*£

61.8±1.0*

Heart Weight(mg)

164.4±9.6

196.1±9.3*

136.4±2.8*+

178.7±4.0

184.2±10.0

132.7±3.0*£

161.2±4.0£

HW/BW ratio(mg/g)

6.2±0.5

3.1±0.1*

4.3±0.3*+

2.7±0.1*

3.1±0.1*

3.8±0.2*

2.6±0.1*

Glycemia(mg/dL)

71±4,5

166±11.8*

142±12.1*

84±5.0+

141±28.6*

153±18.2*

124±8.7*

Total Chol(mg/dL)

93±17

139±10

74±8

145±10

576±78*+

816±74*£

634±55*

Triglycerides(mg/dL)

68±9

68±3

69±5

76±4

210±30*+

301±60*

202±21*

HDL(mg/dL)

73±9

97±6

66±8

100±2

183±15*+

232±21*£

192±4*

LDL(mg/dL)

8±7

29±5

/

34±8

351±66*+

432±24*

402±49*

  1. This table shows the metabolic and phenotypic evolution from 12 till 24 weeks of age of WT (N =13), untreated ob/ob (N =10), untreated DKO (N =13), food-restricted ob/ob (N =32), food-restricted DKO (N =19), ob/ob treated with ACE-I (N =14) and DKO treated with ACE-I (N =16).
  2. * denotes p < 0.05 vs. WT, + p < 0.05 vs. untreated ob/ob and £ p < 0.05 vs. untreated DKO; HW heart weight, BW body weight, Total Chol total cholesterol, HDL high-density lipoprotein, LDL low-density lipoprotein and / = No data available.