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Table 4 Sensitivity, specificity and predicitve values of high sensitive troponin T analyzed 3 to 4 hours after admission and the combination of troponin and copeptin at admission in the final diagnosis of ACS, NSTEMI and UAP

From: The combination of high sensitivity troponin T and copeptin facilitates early rule-out of ACS: a prospective observational study

  hsTnT ≤ 14 ng/L and Copeptin < 14 pmol/L at presentation hsTnT ≤ 14 ng/L after 3-4 hours p-value
  (n = 309) (n = 309)  
ACS    
Sensitivity 86 (74-92) 77 (65-86) 0.031
Specificity 50 (44-56) 68 (62-74) <0.001
NPV 92 (85-96) 91 (86-95)  
PPV 33 (26-40) 41 (32-50)  
NSTEMI    
Sensitivity 98 (87-100) 98 (87-100) 1
Specificity 49 (43-55) 68 (62-73) <0.001
NPV 99 (95-100) 99 (96-100)  
PPV 25 (19-32) 35 (27-44)  
UAP    
Sensitivity 61 (39-80) 35 (17-57) 0.031
Specificity 42 (37-48) 57 (51-63) <0.001
NPV 93 (87-97) 92 (86-95)  
PPV 8 (5-13) 6 (3-12)  
  1. ACS acute coronary syndrome, NPV negative predicitive value, PPV positive predicitive value, NSTEMI non ST-elevation myocardial infarction, UAP unstable angina pectoris.
  2. Sensitivity, Specificity, NPV and PPV are given with corresponding 95% confidence interval.