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Table 1 Population baseline characteristics and sub-analysis according to mean platelet volume

From: Mean platelet volume is associated with the presence of left atrial stasis in patients with non-valvular atrial fibrillation

  Overall MPV ≤ 9.4 fL MPV > 9.4 fL P
  (n = 427) (n = 245) (n = 182)  
Demographics
Age 68.2 ± 10.7 67.5 ± 11.5 69.0 ± 9.3 0.133
32.1% (137) 31.4% (77) 33.0% (60) 0.736
Body Mass Index (Kg/m2) 28.7 ± 5.2 29.2 ± 4.4 28.1 ± 6.0 0.014
Clinical data
Congestive heart failure 49.4% (211) 45.7% (112) 54.4% (99) 0.076
Hypertension 83.4% (356) 83.3% (204) 83.5% (152) 0.945
Diabetes mellitus 24.6% (105) 24.1% (59) 25.3% (46) 0.777
Stroke or TIA 15.2% (65) 12.2% (30) 19.2% (35) 0.047
Vascular diseasea 49.6% (212) 46.5% (114) 53.8% (98) 0.135
AF episode duration >1 week 77.8% (332) 74.7% (183) 81.9% (149) 0.078
CHADS2 score 2.1 ± 1.2 2.0 ± 1.2 2.3 ± 1.3 0.034
CHA2DS2-VASc score 3.7 ± 1.7 3.5 ± 1.8 3.9 ± 1.7 0.081
Medication
Oral anticoagulants 34.4% (147) 33.9% (83) 35.2% (64) 0.782
Enoxaparin 31.1% (133) 32.2% (79) 29.7% (54) 0.570
Antiplatelet agents 48.9% (209) 48.6% (119) 49.5% (90) 0.857
ACE-i or ARB-II 69.6% (297) 65.7% (161) 74.7% (136) 0.045
Statin 41.2% (176) 39.6% (97) 43.4% (79) 0.428
Laboratory assessment
Haemoglobin (g/dL) 13.8 ± 1.9 13.9 ± 1.9 13.6 ± 1.8 0.089
Leukocytes (103/uL) 7.5 ± 3.1 7.4 ± 2.8 7.8 ± 3.6 0.247
Platelets (103/uL) 222.6 ± 86.2 240.6 ± 95.2 198.4 ± 65.1 <0.001
Plaquetocrit (%) 20.5 ± 7.2 20.8 ± 7.9 20.2 ± 6.2 0.774
MPV (fL) 9.3 ± 1.1    
PDW (%) 16.2 ± 1.3 16.1 ± 1.4 16.3 ± 1.2 0.151
INR 1.4 ± 0.7 1.4 ± 0.7 1.4 ± 0.7 0.583
INR ≥ 2.0 17.1% (73) 16.3% (40) 18.1% (33) 0.624
aPTT time (s) 34.1 ± 7.7 33.0 ± 6.0 35.6 ± 9.5 0.078
Creatinine (umol/L) 111.7 ± 93.9 111.4 ± 107.8 112.1 ± 71.4 0.329
Estimated GFR – MDRD 71.1 ± 27.5 72.4 ± 26.8 69.3 ± 28.5 0.262
CRP (mg/L) 1.7 ± 3.5 1.5 ± 2.7 2.1 ± 4.3 0.213
Troponin I (ng/mL) 0.03 ± 0.07 0.03 ± 0.04 0.04 ± 0.10 0.032
Transthoracic echocardiogram data
iLAV (ml/m2) 60.4 ± 24.5 56.7 ± 21.9 64.7 ± 26.6 0.006
iLVdd (mm/m2) 29.6 ± 5.6 28.8 ± 5.5 30.5 ± 5.6 0.010
LVEF < 55% 24.8% (106) 24.5% (60) 25.3% (46) 0.853
  1. Legend: MPV Mean platelet volume, TIA Transient ischemic attack, AF Atrial fibrillation, ACE-i Angiotensin converting enzyme inhibitor, ARB-II Angiotensin II receptor blocker, PDW Platelet distribution width, INR International normalized ratio, CRP, C reactive protein, GFR Glomerular filtration rate, MDRD Modified diet in renal disease formula, LV Left ventricle, LAAT Left atrial appendage thrombi, DSEC Dense spontaneous echo contrast, LFV flow velocities Lowin the left atrial appendage, LA ABN Left atrial abnormality, aPTT Activated partial thromboplastin time, iLAV Indexed left atrial volume, iLVdd Indexed left ventricle diastolic diameter, LVEF Left ventricle ejection fraction.
  2. a vascular disease is defined as having at least one of the following: myocardial infarction, peripheral artery disease and complex aortic plaque.