Observation | Action |
---|---|
Systolic blood pressure < 80 mmHg | Exclusion |
Hemoglobin < 6.5 mmol/l | Exclusion |
> 10% decrease in oxygen saturation | Exclusion |
> 10% decrease in packed cell volume | Exclusion |
> 10% decrease in thrombocytes | Exclusion |
Two times increase in bilirubin* | Exclusion |
Liver transaminases 3–5 times reference limit | Continue in study at half dose of medication |
Liver transaminases >5 times reference limit | Exclusion |