Low sex hormone-binding globulin is associated with hypertension: a cross-sectional study in a Swedish population

Table 4 Association between hypertension and sex hormone-binding globulin when major risk factors for hypertension are considered

		β	p	Exp	β	p	Exp
All	Age	1.352	<0.001	3.9	1.299	<0.001	3.7
	BMI	0.298	0.004	1.3	0.376	0.002	1.5
	HOMA-IR	0.060	0.497	1.1	0.347	0.002	1.4
	SHBG	-0.194	0.061	0.8	-0.297	0.027	0.7
<50	Age	0.619	<0.001	1.9	0.967	<0.001	2.6
	BMI	0.298	0.004	1.3	0.532	0.012	1.7
	HOMA-IR	0.049	0.497	1.1	0.018	0.927	1.0
	SHBG	-0.164	0.061	0.8	-0.103	0.698	0.9
≥50	Age	0.882	<0.001	2.4	0.723	<0.001	2.1
	BMI	0.298	0.004	1.3	0.382	0.012	1.5
	HOMA-IR	0.072	0.491	1.1	0.538	0.001	1.7
	SHBG	-0.210	0.063	0.8	-0.333	0.033	0.7

BMI: Body mass index, HOMA-IR: homeostatic model assessment insulin resistance, SHBG: sex hormone-binding globulin, β: regressions coefficient, p: p value, Exp: the odds change for hypertension for increasing with 1 standard deviation of variable. Age, BMI, HOMA-IR are standardised in order to compare the impact in hypertension. Logistic regression analysis is used to rank the strength of the association. All women with hormonal therapy are excluded from the analyses. Every considered variable is standardised. The purpose was to rank the strength of the association with hypertension for each variable and the value of β decide the strength of the association. We standardised the variables in consideration by the formula SV=V/SD, where SV is the standardised variable. V is the value of the variable and SD is the standard deviation.

ISSN: 1471-2261