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Table 5 Association of selected angiotensinogen haplotypes with cardiovascular disease traits

From: Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population

SNP Block Haplotype Pooled Case Control χ2 P-value
Hypertension
1-8 GGTGGGGT 0.338 0.345 0.314 7.02 0.0081
1-7 GGTGGGG 0.355 0.365 0.327 10.23 0.0014*
2-8 GTGGGGT 0.339 0.347 0.316 7.03 0.008
1-5 GGTGG 0.408 0.417 0.381 8.97 0.0028*
4-8 GGAGT 0.022 0.025 0.013 11.48 0.0007**
4-7 GGAG 0.024 0.027 0.014 13.36 0.0003**
3-7 TGGGG 0.374 0.383 0.347 9.38 0.0022*
1-4 GGTG 0.465 0.475 0.431 13.23 0.0003**
5-8 GAGT 0.026 0.029 0.016 11.40 0.0007**
6-8 AGT 0.028 0.032 0.017 13.77 0.0002**
4-6 GGA 0.026 0.029 0.015 12.50 0.0004**
Myocardial Infarction
1-8 ATTGGGAC 0.057 0.061 0.048 6.68 0.010
1-7 ATTGGGA 0.060 0.065 0.049 8.89 0.0029*
2-8 TTGGGAC 0.059 0.065 0.049 8.68 0.0032*
1-6 ATTGGG 0.077 0.083 0.064 10.72 0.0011**
3-8 TGGGAC 0.094 0.101 0.080 10.71 0.0011*
2-7 TTGGGA 0.063 0.069 0.051 11.40 0.0007*
1-5 ATTGG 0.077 0.083 0.064 11.22 0.0008*
4-8 GGGAC 0.093 0.100 0.080 10.17 0.0014*
1-4 ATTG 0.093 0.101 0.077 13.92 0.0002*
2-6 TTGGG 0.084 0.090 0.073 8.05 0.0046*
2-5 TTGG 0.086 0.092 0.074 8.26 0.0041**
Obesity
1-7 GGCGGAG 0.015 0.021 0.012 10.08 0.0015**
2-8 GCGGAGT 0.014 0.019 0.011 9.22 0.0024**
1-6 GGCGGA 0.015 0.020 0.012 8.93 0.0028**
3-8 CGGAGT 0.014 0.019 0.011 8.73 0.0031**
4-8 GGAGT 0.022 0.029 0.018 10.96 0.0009**
3-7 CGGAG 0.015 0.020 0.012 9.03 0.0027**
5-8 GAGT 0.026 0.033 0.022 9.95 0.0016*
6-8 AGT 0.028 0.035 0.024 9.62 0.0019*
4-6 GGA 0.026 0.034 0.021 15.94 0.00005**
  1. The most frequent 8-mer haplotype GGTGGGGT (0.338) was employed as the baseline to determine the relative effects of the other haplotypes. Number 1 denotes rs2067853, 2 is rs7079, 3 is rs1926723, 4 is rs699, 5 is rs4762, 6 is rs3789679, 7 is rs2148582 and 8 is rs5051 arranged sequentially by their chromosomal positions, and blocks represent the range of variants constituting the respective haplotypes. *P < 0.005, **P < 0.001 by χ2 test.