Skip to main content

Table 5 Association of selected angiotensinogen haplotypes with cardiovascular disease traits

From: Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population

SNP Block

Haplotype

Pooled

Case

Control

χ2

P-value

Hypertension

1-8

GGTGGGGT

0.338

0.345

0.314

7.02

0.0081

1-7

GGTGGGG

0.355

0.365

0.327

10.23

0.0014*

2-8

GTGGGGT

0.339

0.347

0.316

7.03

0.008

1-5

GGTGG

0.408

0.417

0.381

8.97

0.0028*

4-8

GGAGT

0.022

0.025

0.013

11.48

0.0007**

4-7

GGAG

0.024

0.027

0.014

13.36

0.0003**

3-7

TGGGG

0.374

0.383

0.347

9.38

0.0022*

1-4

GGTG

0.465

0.475

0.431

13.23

0.0003**

5-8

GAGT

0.026

0.029

0.016

11.40

0.0007**

6-8

AGT

0.028

0.032

0.017

13.77

0.0002**

4-6

GGA

0.026

0.029

0.015

12.50

0.0004**

Myocardial Infarction

1-8

ATTGGGAC

0.057

0.061

0.048

6.68

0.010

1-7

ATTGGGA

0.060

0.065

0.049

8.89

0.0029*

2-8

TTGGGAC

0.059

0.065

0.049

8.68

0.0032*

1-6

ATTGGG

0.077

0.083

0.064

10.72

0.0011**

3-8

TGGGAC

0.094

0.101

0.080

10.71

0.0011*

2-7

TTGGGA

0.063

0.069

0.051

11.40

0.0007*

1-5

ATTGG

0.077

0.083

0.064

11.22

0.0008*

4-8

GGGAC

0.093

0.100

0.080

10.17

0.0014*

1-4

ATTG

0.093

0.101

0.077

13.92

0.0002*

2-6

TTGGG

0.084

0.090

0.073

8.05

0.0046*

2-5

TTGG

0.086

0.092

0.074

8.26

0.0041**

Obesity

1-7

GGCGGAG

0.015

0.021

0.012

10.08

0.0015**

2-8

GCGGAGT

0.014

0.019

0.011

9.22

0.0024**

1-6

GGCGGA

0.015

0.020

0.012

8.93

0.0028**

3-8

CGGAGT

0.014

0.019

0.011

8.73

0.0031**

4-8

GGAGT

0.022

0.029

0.018

10.96

0.0009**

3-7

CGGAG

0.015

0.020

0.012

9.03

0.0027**

5-8

GAGT

0.026

0.033

0.022

9.95

0.0016*

6-8

AGT

0.028

0.035

0.024

9.62

0.0019*

4-6

GGA

0.026

0.034

0.021

15.94

0.00005**

  1. The most frequent 8-mer haplotype GGTGGGGT (0.338) was employed as the baseline to determine the relative effects of the other haplotypes. Number 1 denotes rs2067853, 2 is rs7079, 3 is rs1926723, 4 is rs699, 5 is rs4762, 6 is rs3789679, 7 is rs2148582 and 8 is rs5051 arranged sequentially by their chromosomal positions, and blocks represent the range of variants constituting the respective haplotypes. *P < 0.005, **P < 0.001 by χ2 test.