Ankle-brachial index and the incidence of cardiovascular events in the Mediterranean low cardiovascular risk population ARTPER cohort

Table 2 Incidence of cardiovascular events among different ankle-brachial index groups

	Total n = 3307				ABI 0.9-1.4 n = 2916				ABI < 0.9 n = 193								ABI ≥ 1.4 n = 198
	n	I	CI95%		n	I	CI95%		n	I	CI95%		HR	CI95%		p	n	I	CI95%		HR	CI95%		p
Coronary disease	140	1124	946	1327	105	953	780	1154	27	3808	2510	5541	2.0	1.3	3.2	0.003	8	1100	475	2168	0.8	0.4	1.6	0.522
Cerebrovascular disease	107	853	699	1031	80	723	573	899	14	1895	1036	3180	1.2	0.7	2.3	0.505	13	1783	949	3049	1.9	1.0	3.5	0.051
SAAA*	19	150	90	235	14	125	69	211	4	537	146	1374	3.1	0.9	9.9	0.063	1	135	3	754	0.8	0.1	6.4	0.857
Vascular surgery	45	357	260	478	29	260	174	374	14	1941	1061	3257	5.6	2.8	11.5	<0.001	2	271	33	978	0.9	0.2	3.6	0.831
Cardiovascular morbidity	260	2117	1868	2391	191	1754	1514	2021	48	7104	5238	9418	2.1	1.5	2.9	<0.001	21	2935	1817	4487	1.2	0.7	1.9	0.474
Mortality	124	978	814	1166	95	849	687	1038	20	2657	1623	4104	1.5	0.9	2.4	0.141	9	1216	556	2308	1.0	0.5	2.0	0.947
Vascular	29	229	153	329	19	170	102	265	8	1063	459	2094	2.4	1.0	6.0	0.060	2	270	33	976	1.2	0.3	5.1	0.847
Non vascular	95	749	606	916	76	680	535	851	12	1594	824	2785	1.2	0.6	2.2	0.598	7	945	380	1948	1.0	0.5	2.2	0.947
Morbi-mortality	347	2826	2536	3139	263	2415	2132	2726	59	8731	6647	11263	1.8	1.4	2.5	<0.001	25	3495	3495	5159	1.0	0.7	1.6	0.838

ABI: ankle-brachial index, PAD: peripheral arterial disease, AC: arterial calcification.
*: SAAA: symptomatic aneurysm of the abdominal aorta.
Individuals with prevalent events excluded.
I = incidence per 100,000 person-year.
CI95% = 95% confidence interval of incidence (Poisson distribution) or of hazard ratio (Cox model).
HR = adjusted hazard ratio (reference ABI 0.9-1.4). HR are based on 2,799 healthy, 187 peripheral arterial disease and 189 arterial calcification subjects.
HR are adjusted by age, gender, smoking, central and general obesity, hypertension, hypercholesterolemia and diabetes.
p = p-value of HR different than 1.

ISSN: 1471-2261