Transcatheter patent foramen ovale closure versus medical therapy for cryptogenic stroke: a meta-analysis of randomized clinical trials

Table 5 Primary endpoint meta-analysis

Endpoint	Closure Trial		PC Trial		Respect Trial		Random Effects Model
Endpoint	HR	95%CI	HR	95%CI	HR	95%CI	HR	95% CI	p-value
ITT Population
Composite endpoint of all devices	0.78	0.45,1.35	0.63	0.24,1.62	0.49	0.22,1.11	0.66	0.43,1.01	0.06
Composite endpoint of Amplatzer device			0.63	0.24,1.62	0.49	0.22,1.11	0.54	0.29,1.01	0.05
Per Protocol
Composite endpoint of all devices	0.74	0.42,1.29	0.70	0.27,1.85	0.37	0.14,0.96	0.64	0.41,0.98	0.04
Composite endpoint of Amplatzer device			0.70	0.27,1.85	0.37	0.14,0.96	0.64	0.44,0.97	0.03

ISSN: 1471-2261