Table 3 Summary of subgroup analysis
Subgroup | CLOSURE Trial | PC Trial | RESPECT Trial | |||
|---|---|---|---|---|---|---|
| Â | Closure | Medical | Closure | Medical | Closure | Medical |
Sex (%) | ||||||
Male | 3.4 | 6.8 | NA | NA | 1.9 | 3.7 |
Female | 7.9 | 7.0 | NA | NA | 1.7 | 2.8 |
Atrial Septal Aneurysm (%) | ||||||
No | 6.2 | 7.4 | 1.9 | 5.7 | 2.2 | 2.2 |
Yes | 4.6 | 6.0 | 8.5 | 3.9 | 1.1 | 5.3 |
Age (%) | ||||||
≤ 45 yr | NA | NA | 1.1 | 6.2 | 1.7 | 2.4 |
> 45Â yr | NA | NA | 5.3 | 4.4 | 1.9 | 4.1 |
Cardiovascular index event (%) | ||||||
Stroke | 5.1 | 5.1 | 3.0 | 4.9 | NA | NA |
TIA or Peripheral Embolism | 7.1 | 11.6 | 5.1 | 6.4 | NA | NA |
Shunt size (%) | ||||||
None to Moderate | 5.7 | 6.9 | NA | NA | 2.8 | 2.5 |
Substantial | 3.5 | 4.9 | NA | NA | 0.8 | 4.3 |