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Table 2 Multiple regression analysis with cardiovascular and renal covariants, and serum uric acid as dependent variable

From: Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study

 

Men n = 2696

Women n = 3004

Men and women n = 5700

 

β (95% CI*)

Std. β-coeffcent.ϯ

P-value

β (95% CI*)

Std. β-coeffcent.ϯ

P-value

β (95% CI*)

Std. β-coeffcent.ϯ

P-value

Model 1

         

Intercept

175 (143, 208)

-

<0.001

71 (52, 90)

-

<0.001

128 (108, 148)

-

<0.001

Age

-0.70 (-0.10, -0.39)

-0.09

<0.001

0.55 (0.30, 0.80)

0.08

<0.001

-0.39 (-0.61, -0.17)

-0.05

0.001

BMI

8.29 (7.38, 9.21)

0.33

<0.001

5.31 (4.73, 5.88)

0.32

<0.001

6.79 (6.21, 7.37)

0.30

<0.001

SBP

0.06 (-0.10, 0.21)

0.01

0.49

0.24 (0.13, 0.35)

0.08

< 0.001

0.24 (0.13, 0.35)

0.06

<0.001

Adjusted R2

0.12

  

0.15

  

0.10

  

Model 2

         

HDL-cholesterol

-44.42 (-52.09, -36.76)

-0.22

<0.001

-27.68 (-33.12,-22.23)

-0.17

<0.001

-61.58 (-66.42, -56.74)

-0.32

<0.001

Cholesterol

10.12 (7.70, 12.54)

0.15

<0.001

6.38 (4.50, 8.26)

0.12

<0.001

6.33 (4.67, 7.99)

0.10

<0.001

Adjusted R2

 

0.17

 

0.18

  

0.19

  

Model 3

         

Antihypertensive

         

Drugs

26.10 (16.76, 35.44)

0.10

<0.001

14.19 (6.55, 21.83)

0.06

0.001

20.37 (13.66, 27.08)

0.07

<0.001

Diuretics

66.90 (33.13, 99.98)

0.07

<0.001

69.14 (51.01, 87.28)

0.13

<0.001

54.52 (35.75, 73.29)

0.07

<0.001

Adjusted R2

0.18

  

0.20

  

0.20

  

Model 4

         

Current smoker

-7.73 (-13.81, -1.63)

-0.04

0.01

2.07 (-3.02, 7.16)

0.01

0.4

-0.80 (-5.23, 3.62)

-0.004

0.7

Physical activity

-7.29 (-13.56, -1.02)

-0.04

0.02

1.17 (-5.27, 7.61)

0.01

0.7

11.28 (6.35, 16.20)

0.05

<0.001

Adjusted R2

0.19

  

0.20

  

0.20

 

Model 5

         

GFR ckd-epi

-1.76 (-2.05, -1.48)

-0.28

<0.001

-1.73 (-1.94, -1.51)

-0.32

<0.001

-1.74 (-1.91,-1.56)

-0.27

<0.001

logACR

4.09 (-2.58, 10.76)

0.02

0.23

15.41 (9.28, 21.55)

0.08

< 0.001

8.09 (3.58, 12.61)

0.04

<0.001

Gender

- -

-

-

- -

-

-

76.87 (73.08, 80.66)

0.44

<0.001

Adjusted R2

0.23

  

0.27

  

0.40

  
  1. *Confidence interval. ϯStandarized β-coeffcient. Gender: 1 = male, 0 = female, GFR: Glomerular filtration rate according to the CKD EPI formula [17].
  2. ACR: urinary albumin/creatinine ratio (mean of 3 urine samples) logACR: logarithmic transformation of ACR. Model 1: Age, body mass index.
  3. (BMI), systolic blood pressure (SBP). Model 2: Model 1 + HDL-cholesterol and total cholesterol. Model 3: Model 2 + use of diuretics and other anti-hypertensive medication. Model 4: Model 3 + current smoking and physical activity (self-reported hard physical activity ≥1 hr per week; yes = 1 / no = 0), current smoking (yes = 1 / no = 0). Model 5: Model 4 + renal factors added (GFR the CKD-EPI and logACR).
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