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Table 2 Histomorphometric and Histopathologic Finding at 14 Days and 28 Days Following Implantation of GS, SES, or HCASES in Porcine Coronary Arteries

From: Combination coating of chitosan and anti-CD34 antibody applied on sirolimus-eluting stents can promote endothelialization while reducing neointimal formation

Histological results GS SES HCASES P value
14 days(n=9 each)     
Injury score 0.77±0.24 0.84±0.19 0.92±0.26 0.436
Inflammation score 1.64±0.38§ 1.01±0.21 0.81±0.29§ 0.482
IEL area(mm2) 4.11±0.46 3.93±0.82 3.99±0.36 0.085
Lumen area (mm2) 2.76±0.43 2.99±0.53 2.84±0.33 0.091
Intimal area(mm2) 1.82±0.94 1.34±0.49 1.58±0.66 0.058
Neointimal thickness(μm) 145.39±72.57 112.72±38.52 136.17±51.94 0.072
Percent of stenosis (%) 17.88±8.24 13.94±5.21 15.68±7.03 0.066
28 days(n=9 each)     
IEL area(mm2) 4.76±0.84 4.36±0.53 4.49±0.46 0.658
Lumen area (mm2) 1.96±0.47§ 2.78±0.36* 2.55±0.62§* 0.037
Intimal area(mm2) 2.80±0.37§ 1.58±0.17* 1.94±0.84§* 0.024
Neointimal thickness(μm) 276.25±108.36§ 131.44±43.85* 184.53±87.29§* 0.022
Percent of stenosis (%) 33.74±11.85§ 16.48±7.31* 20.51±9.43§* 0.031
Injury score 0.81±0.14 0.79±0.24 0.82±0.16 0.462
Inflammation score 1.69±0.33§ 1.21±0.72 1.07±0.56§ 0.447
  1. Data are mean±SD. IEL, internal elastic lamina.
  2. * P<0.05 for SES vs HCASES.
  3. § P<0.05 for GS vs HCASES.
  4. P<0.05 for GS vs SES.
  5. GS = anti-CD34 antibody stent; SES= sirolimus-eluting stent.
  6. HCASES = HC-anti-CD34 antibody combined with a sirolimus-eluting stent.