Skip to main content

Table 2 Histomorphometric and Histopathologic Finding at 14 Days and 28 Days Following Implantation of GS, SES, or HCASES in Porcine Coronary Arteries

From: Combination coating of chitosan and anti-CD34 antibody applied on sirolimus-eluting stents can promote endothelialization while reducing neointimal formation

Histological results

GS

SES

HCASES

P value

14 days(n=9 each)

    

Injury score

0.77±0.24

0.84±0.19

0.92±0.26

0.436

Inflammation score

1.64±0.38§

1.01±0.21

0.81±0.29§

0.482

IEL area(mm2)

4.11±0.46

3.93±0.82

3.99±0.36

0.085

Lumen area (mm2)

2.76±0.43

2.99±0.53

2.84±0.33

0.091

Intimal area(mm2)

1.82±0.94

1.34±0.49

1.58±0.66

0.058

Neointimal thickness(μm)

145.39±72.57

112.72±38.52

136.17±51.94

0.072

Percent of stenosis (%)

17.88±8.24

13.94±5.21

15.68±7.03

0.066

28 days(n=9 each)

    

IEL area(mm2)

4.76±0.84

4.36±0.53

4.49±0.46

0.658

Lumen area (mm2)

1.96±0.47§

2.78±0.36*

2.55±0.62§*

0.037

Intimal area(mm2)

2.80±0.37§

1.58±0.17*

1.94±0.84§*

0.024

Neointimal thickness(μm)

276.25±108.36§

131.44±43.85*

184.53±87.29§*

0.022

Percent of stenosis (%)

33.74±11.85§

16.48±7.31*

20.51±9.43§*

0.031

Injury score

0.81±0.14

0.79±0.24

0.82±0.16

0.462

Inflammation score

1.69±0.33§

1.21±0.72

1.07±0.56§

0.447

  1. Data are mean±SD. IEL, internal elastic lamina.
  2. * P<0.05 for SES vs HCASES.
  3. § P<0.05 for GS vs HCASES.
  4. P<0.05 for GS vs SES.
  5. GS = anti-CD34 antibody stent; SES= sirolimus-eluting stent.
  6. HCASES = HC-anti-CD34 antibody combined with a sirolimus-eluting stent.