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Table 4 Difference in systolic blood pressure between celecoxib and ibuprofen or naproxen after propensity score matching

From: Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension

     Comparison Dependent Variable* Estimate of SBP(mmHg)** 95% Confidence Interval
Celecoxib vs. Ibuprofen (n=226) First SBP −5.4 −10.8 to 0.0
  Average SBP −5.2 −10.0 to −0.4
Celecoxib vs. Naproxen (n=204) First SBP −0.3 −5.5 to 4.9
  Average SBP −0.3 −5.1 to 4.5
  1. SBP: Systolic blood pressure.
  2. * First SBP is the first systolic blood pressure measurement after the index date. Average SBP is the average of all systolic blood pressure measurements after the index date and prior to any changes in the antihypertensive therapy.
  3. ** Estimate of SBP is the estimate difference between celecoxib and the comparator drug (ibuprofen or naproxen) after controlling for baseline SBP. A positive value means celecoxib is associated with higher increase in systolic blood pressure compared to the comparator drug. A negative value means the comparator drug is associated with higher increase in systolic blood pressure compared to celecoxib.