Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension

Table 3 Difference in systolic blood pressure between naproxen and ibuprofen after propensity score matching

Sample	Dependent Variable*	Estimate of SBP (mmHg)**	95% Confidence Interval
All Patients (n=944)	First SBP	−2.0	−4.4 to 0.4
	Average SBP	−2.5	−4.6 to −0.5
ACE-I (n=276)	First SBP	0.7	−4.1 to 5.4
	Average SBP	−1.1	−5.3 to 3.0
CCB (n=268)	First SBP	−2.3	−6.8 to 2.2
	Average SBP	−2.2	−6.1 to 1.7
BB (n=130)	First SBP	−4.3	−10.6 to 2.0
	Average SBP	−5.9	−11.7 to −0.01
Diuretics (n=340)	First SBP	−3.2	−7.6 to 1.2
	Average SBP	−3.3	−7.0 to 0.5
CCB & ACE-I (n=60)	First SBP	0.4	−11.9 to 12.7
	Average SBP	−0.8	−11.7 to 10.1
CCB & BB (n=34)	First SBP	−4.5	−18.8 to 9.7
	Average SBP	−4.4	−18.3 to 9.6
CCB & diuretics (n=118)	First SBP	−3.2	−11.3 to 5.0
	Average SBP	−3.2	−9.5 to 3.2
ACE-I & BB (n=40)	First SBP	−5.8	−19.1 to 7.5
	Average SBP	−10.1	−23.0 to 2.8
ACE-I & diuretics (n=124)	First SBP	−3.3	−10.5 to 4.0
	Average SBP	−4.3	−11.0 to 2.5
BB & diuretics (n=70)	First SBP	−7.0	−16.3 to 2.4
	Average SBP	−5.4	−14.0 to 3.2
CCB & ACE-I & diuretics (n=28)	First SBP	−4.6	−22.9 to 13.8
	Average SBP	−0.5	−16.5 to 15.6
BB & ACE-I & diuretics (n=22)	First SBP	−7.4	−29.2 to 14.4
	Average SBP	−8.9	−30.8 to 13.0

ACE-I: Angiotensin converting enzyme inhibitor; BB: Beta-blocker; CCB: Calcium channel blocker; SBP: Systolic blood pressure.
* First SBP is the first systolic blood pressure measurement after the index date. Average SBP is the average of all systolic blood pressure measurements after the index date and prior to any changes in the antihypertensive therapy.
** Estimate of SBP is the estimate difference between naproxen and ibuprofen after controlling for baseline SBP. A positive value means naproxen is associated with higher increase in systolic blood pressure compared to ibuprofen. A negative value means ibuprofen is associated with higher increase in systolic blood pressure compared to naproxen.