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Table 2 Difference in systolic blood pressure between NSAIDs and acetaminophen after propensity score matching

From: Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension

Sample Dependent Variable* Estimate of SBP (mmHg)** 95% Confidence Interval
All Patients (n=2,680) First SBP 1.8 0.3 to 3.3
  Average SBP 2.0 0.7 to 3.3
ACE-I (n=768) First SBP 2.8 −0.2 to 5.8
  Average SBP 2.8 0.2 to 5.4
CCB (n=804) First SBP 2.5 −0.4 to 5.4
  Average SBP 3.2 0.6 to 5.7
BB (n=340) First SBP 6.3 1.7 to 10.8
  Average SBP 5.5 1.4 to 9.6
Diuretics (n=1,022) First SBP 0.2 −2.3 to 2.8
  Average SBP 1.3 −0.8 to 3.4
CCB & ACE-I (n=202) First SBP 1.1 −5.6 to 7.8
  Average SBP 3.1 −2.8 to 8.9
CCB & BB (n=104) First SBP 4.0 −5.0 to 13.0
  Average SBP 6.0 −2.0 to 14.1
CCB & diuretics (n=328) First SBP 1.6 −3.3 to 6.5
  Average SBP 3.5 −0.8 to 7.9
ACE-I & BB (n=108) First SBP 7.5 −1.0 to 16.0
  Average SBP 6.7 −1.1 to 14.5
ACE-I & diuretics (n=366) First SBP 1.0 −3.4 to 5.5
  Average SBP 1.2 −2.7 to 5.1
BB & diuretics (n=156) First SBP 3.8 −3.9 to 11.5
  Average SBP 4.2 −2.8 to 11.3
CCB & ACE-I & diuretics (n=100) First SBP 1.5 −7.9 to 10.8
  Average SBP 3.8 −4.9 to 12.4
BB & ACE-I & diuretics (n=42) First SBP 6.8 −9.4 to 22.9
  Average SBP 5.4 −10.3 to 21.1
  1. ACE-I: Angiotensin converting enzyme inhibitor; BB: Beta-blocker; CCB: Calcium channel blocker; SBP: Systolic blood pressure.
  2. * First SBP is the first systolic blood pressure measurement after the index date. Average SBP is the average of all systolic blood pressure measurements after the index date and prior to any changes in the antihypertensive therapy.
  3. ** Estimate of SBP is the estimate difference between NSAIDs and acetaminophen after controlling for baseline SBP. A higher value means NSAIDs is associated with higher increase in systolic blood pressure compared to acetaminophen.