Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels

Table 4 Effect of interaction between serum lipid levels and genetic variants at 1p13 on the risk of MI expressed as Odds Ratio (OR) and 95%CI in the SHEEP

		N	OR (95%CI)		N	OR (95%CI)		N	OR (95%CI)
Rs599839	ApoB ≥75^th perc	617	2.27	Tot-chol ≥75^th perc	611	1.72	LDL-chol ≥75^th perc	1304	1.63
Rs599839	ApoB ≥75^th perc	617	(1.86-2.77)	Tot-chol ≥75^th perc	611	(1.40-2.10)	LDL-chol ≥75^th perc	1304	(1.32-2.01)
	AG + GG vs AA	601	1.34	AG + GG vs AA	562	1.13	AG + GG vs AA	188	1.13
	AG + GG vs AA	601	(1.10-1.64)		562	(0.93-1.37)	AG + GG vs AA	188	(0.94-1.37)
	Both	234	1.76	Both	474	1.80	Both	474	1.68
	Both	234	(1.33-2.34)	Both	474	(1.36-2.37)	Both	474	(1.24-2.27)
S (95%CI)			0.47			0.94			0.89
S (95%CI)			(0.24-0.90)			(0.46-1.92)			(0.38-2.06)
Rs646776	ApoB ≥75^th perc	536	2.18	Tot-chol ≥75th perc	582	1.79	LDL-chol ≥75th perc	416	1.54
Rs646776	ApoB ≥75^th perc	536	(1.76-2.70)	Tot-chol ≥75th perc	582	(1.45-2.20)	LDL-chol ≥75th perc	416	(1.23-1.93)
	CC + CT vs TT	787	1.09	CC + CT vs TT	751	0.98	CC + CT vs TT	837	0.94
	CC + CT vs TT	787	(0.90-1.33)	CC + CT vs TT	751	(0.81-1.19)	CC + CT vs TT	837	(0.79-1.13)
	Both	312	1.79	Both	350	1.76	Both	243	1.68
	Both	312	(1.38-2.32)	Both	350	(1.37-2.25)	Both	243	(1.27-2.23)
S (95%CI)			0.62			0.97			1.39
			(0.34-1.12)			(0.50-1.89)			(0.53-3.63)

The table provides the OR (95%CI) relative to the risk of MI associated with the exposure to high serum levels of ApoB, total-cholesterol (tot-chol), LDL-cholesterol (LDL-chol) in the absence of the allele G at rs599839 and of the allele C at rs646776 in the first row of the two sections; the risk associated with the exposure to the allele G or C in the absence of the exposure to high lipid serum levels in the second row of each section and the risk associated with the exposure to both serum levels and genotype in the third row of each section. The last row of each section reports the S index along with the 95%CI.

ISSN: 1471-2261