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Table 4 Effect of interaction between serum lipid levels and genetic variants at 1p13 on the risk of MI expressed as Odds Ratio (OR) and 95%CI in the SHEEP

From: Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels

   N OR (95%CI)   N OR (95%CI)   N OR (95%CI)
Rs599839 ApoB ≥75th perc 617 2.27 Tot-chol ≥75th perc 611 1.72 LDL-chol ≥75th perc 1304 1.63
(1.86-2.77) (1.40-2.10) (1.32-2.01)
  AG + GG vs AA 601 1.34 AG + GG vs AA 562 1.13 AG + GG vs AA 188 1.13
(1.10-1.64)   (0.93-1.37) (0.94-1.37)
  Both 234 1.76 Both 474 1.80 Both 474 1.68
(1.33-2.34) (1.36-2.37) (1.24-2.27)
S (95%CI)    0.47    0.94    0.89
(0.24-0.90) (0.46-1.92) (0.38-2.06)
Rs646776 ApoB ≥75th perc 536 2.18 Tot-chol ≥75th perc 582 1.79 LDL-chol ≥75th perc 416 1.54
(1.76-2.70) (1.45-2.20) (1.23-1.93)
  CC + CT vs TT 787 1.09 CC + CT vs TT 751 0.98 CC + CT vs TT 837 0.94
(0.90-1.33) (0.81-1.19) (0.79-1.13)
  Both 312 1.79 Both 350 1.76 Both 243 1.68
(1.38-2.32) (1.37-2.25) (1.27-2.23)
S (95%CI)    0.62    0.97    1.39
    (0.34-1.12)    (0.50-1.89)    (0.53-3.63)
  1. The table provides the OR (95%CI) relative to the risk of MI associated with the exposure to high serum levels of ApoB, total-cholesterol (tot-chol), LDL-cholesterol (LDL-chol) in the absence of the allele G at rs599839 and of the allele C at rs646776 in the first row of the two sections; the risk associated with the exposure to the allele G or C in the absence of the exposure to high lipid serum levels in the second row of each section and the risk associated with the exposure to both serum levels and genotype in the third row of each section. The last row of each section reports the S index along with the 95%CI.