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Table 3 Hazard ratio (HR) estimates of adverse events among patients treated with zotarolimus-eluting stents (ZES) or sirolimus-eluting stents (SES) in western denmark, August 2005 to October 2007

From: Comparison of zotarolimus-eluting and sirolimus-eluting coronary stents: a study from the Western Denmark Heart Registry

Endpoint

Period (days)

Patients with ZES

Patients with SES

Adjusted HR* (95% CI)

P Value

  

No. of events

No./100 person-year

No. of events

No./100 person-year

  

Patient level analysis

 

N = 2,282

N = 3,840

  

Death

0-823

135

6.3

159

3.3

1.35 (1.05-1.73)

0.018

 

0-30

57

31.0

50

16.0

1.66 (1.10-2.50)

0.016

 

31-365

62

4.1

70

2.4

1.19 (0.82-1.73)

0.388

 

366-823

16

3.5

39

2.5

1.26 (0.67-2.34)

0.475

Cardiac death

0-823

57

2.7

59

1.2

1.33 (0.89-2.00)

0.183

 

0-30

32

17.4

29

9.3

1.39 (0.80-2.41)

0.229

 

31-365

21

1.4

23

0.8

1.17 (0.59-2.32)

0.711

 

366-823

4

0.9

7

0.4

1.36 (0.31-5.95)

0.687

Noncardiac death

0-823

53

2.5

66

1.4

1.27 (0.87-1.87)

0.217

 

0-30

16

8.7

20

6.4

1.32 (0.65-2.66)

0.467

 

31-365

31

2.1

34

2.1

1.25 (0.75-2.09)

0.397

 

366-823

6

1.3

12

0.8

1.39 (0.50-3.89)

0.532

Myocardial infarction

31-823

66

3.5

108

2.5

0.98 (0.69-1.42)

0.964

 

366-823

9

2.1

30

2.0

0.99 (0.43-2.28)

0.992

Target lesion revascularization

0-823

110

5.3

91

1.9

2.16 (1.36-3.42)

0.001

Stent thrombosis

0-823

26

1.2

24

0.5

2.01 (0.76-5.34)

0.159

 

0-30

21

11.5

13

4.2

3.62 (0.92-14.2)

0.065

 

31-365

4

0.3

5

0.2

1.17 (0.18-7.39)

0.870

 

366-823

1

0.2

6

0.4

Not calculable

-

Lesion level analysis

 

N = 3,090

N = 5,095

  

Target lesion revascularization

0-823

115

4.0

96

1.5

2.48 (1.87-3.27)

<0.0001

Stent thrombosis

0-823

28

1.0

24

0.4

2.21 (1.26-3.87)

0.006

 

0-30

23

9.3

13

3.1

2.75 (1.38-5.47)

0.004

 

31-365

4

0.2

5

0.1

1.47 (0.39-5.57)

0.568

 

366-823

1

0.2

6

0.3

1.22 (0.14-10.9)

0.857

  1. *The patient level analyses were adjusted for age, sex, Charlson Comorbidity score, diabetes mellitus, PCI indication, procedure time, no. of treated lesions, total stent length, and total no. of stents. The lesion level analyses were adjusted for age, sex, diabetes mellitus, PCI indication, procedure time, and stent length.
  2. Defined as late (>30 days) definite stent thrombosis, myocardial infarction, or death from any cause.