Effect of statin therapy on the progression of coronary atherosclerosis

Table 2 Stratified analyses by dose and duration of follow-up of statin therapy

Subgroup	Number of studies	Number of patients	I ²index	PV change (95% CI)	P
1	3	99	0%	−5.4 mm³ (−13.8, 3.0)	0.21
2	5	415	59%	−7.8 mm³ (−20.2, 4.5)	0.21
3	2	41	0%	−5.6 mm³ (−22.3, 11.2)	0.52
4	9	1,520	0%	−5.2 mm³ (−7.3, –3.1)	<0.001

Abbreviations: PV, plaque volume. Subgroup 1: ≤10 mg/day of atorvastatin or an equivalent dose of other statins and ≤6 months of follow-up; subgroup 2: ≤10 mg/day of atorvastatin or an equivalent dose of other statins and >6 months of follow-up; subgroup 3: >10 mg/day of atorvastatin or an equivalent dose of other statins and ≤6 months of follow-up; subgroup 4: >10 mg/day of atorvastatin or an equivalent dose of other statins and >6 months of follow-up. I ² index: degree of heterogeneity in the meta-analysis.

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