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·Preregistered participant of the 38th BMW BERLIN-MARATHON 2011
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·Age ≥ 35 and ≤ 60 years
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·Marathon history: at least 2 marathon runs within the last 5 years
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·Amount of physical activity: running for at least 40 km per week
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·Sinus rhythm on the day of enrolment
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Exclusion criteria
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·Known cardiac disease or cardiac arrhythmia
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·Known stroke or TIA, brain tumour or infectious disease affecting the brain
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·Contraindications for magnetic resonance imaging
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·Acute cerebral infarction or other clinical relevant pathological findings detected by brain magnetic resonance imaging before the marathon
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·Severe liver or kidney disease
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·Hyperthyroidism, pregnancy or lactation
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