Higher incidence of death in multi-vessel coronary artery disease patients associated with polymorphisms in chromosome 9p21

Table 2 Cardiovascular end-points

	rs10757274			P	rs2383206			P	rs10757278			P	rs1333049			P
	N = 498				N = 495				N = 496				N = 507
Events	AA	AG	GG		AA	AG	GG		AA	AG	GG		CC	GC	GG
Refractory angina	17.9%	18.5%	15.9%	0.82	19.0%	16.0%	17.2%	0.81	19.1%	17.0%	16.4%	0.84	15.8%	17.4%	19.1%	0.79
PCI	9.8%	13.8%	9.5%	0.35	9.5%	12.2%	10.3%	0.73	11.3%	11.9%	10.9%	0.96	10.8%	12.6%	11.3%	0.84
MI	8.9%	7.7%	7.9%	0.92	10.7%	8.0%	6.3%	0.47	9.6%	7.9%	6.3%	0.63	6.5%	7.5%	9.6%	0.65
Cardiac death	8.9%	9.2%	11.1%	0.81	8.3%	7.2%	13.2%	0.11	8.7%	7.5%	13.3%	0.18	11.5%	9.5%	7.0%	0.47
Total death	11.6%	13.8%	17.5%	0.42	11.9%	11.0%	19.5%	0.04	12.2%	13.0%	17.2%	0.45	15.8%	14.6%	11.3%	0.57
Total events	25.9%	29.2%	26.2%	0.73	27.4%	25.3%	27.4%	0.74	26.1%	27.3%	27.3%	0.97	25.9%	28.9%	25.2%	0.71

N = number of samples genotyped.
Refractory angina = requiring either angioplasty or surgery; PCI = angioplasty; MI = myocardial infarction; Cardiac death = death from cardiac causes; Total death = overall mortality; Total events = refractory angina requiring angioplasty or surgery + angioplasty + myocardial infarction + death from cardiac causes + overall mortality.

ISSN: 1471-2261