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Table 4 Association between ACE I/D polymorphisms and ACS sudden cardiac death

From: Angiotensin converting enzyme DD genotype is associated with acute coronary syndrome severity and sudden cardiac death in Taiwan: a case-control emergency room study

Subject characteristics Survival Expired Univariate   Multivariate  
  (n = 99) (n = 12) OR (95%CI) p* OR (95% CI) p*
ACE-genotypes       
II 35 2 1 (ref.)   1 (ref.)  
ID 47 4 1.489 (0.258-8.595) 0.656 1.659 (0.264-10.427) 0.589
DD 17 6 6.176 (1.126-33.876) 0.036 6.484 (1.036-40.598) 0.046
ACS spectrum       
UAP (n = 57) 54 3 1 (ref.)    
AMI (n = 54) 45 9 3.600 (0.919-14.100) 0.066   
Demographic factors       
Age 65.02 ± 13.40 64.85 ± 17.90 0.999 (0.956-1.043) 0.949 - -
Sex -Female 21 4 1 (ref.)    
Male 78 8 1.857 (0.510-6.769) 0.348 - -
Complications       
Hypertension- No 36 5 1 (ref.)   - -
- Yes 63 7 0.800 (0.237-2.706) 0.720   
Diabetes Mellitus-No 68 7 1 (ref.)   - -
- Yes 31 5 1.567 (0.461-5.327) 0.472   
Hypercholesterolemia-No 78 11    - -
- Yes 21 1 0.338 (0.041-2.766) 0.312   
Other clinical risk factors       
Systolic blood pressure 67 6 1(ref.)   - -
< 140 mmHg       
≥ 140 mmHg 32 6 2.094 (0.626-7.003) 0.230   
Diastolic blood pressure 78 10 1 (ref.)   - -
< 90 mmHg       
≥ 90 mmHg 21 2 0.743 (0.151-3.653) 0.715   
Total cholesterol 83 11 1 (ref.) - -  
< 200 mg/dl       
≥ 200 mg/dl 16 1 0.472 (0.057-3.913) 0.486   
Triglyceride < 150 mg/dl 81 11 1 (ref.) - -  
≥ 150 mg/dl 18 1 0.409 (0.050-3.374) 0.406   
BMI (kg/m2) < 27 88 11 1 (ref.) - -  
≥ 27 11 1 0.727 (0.085-6.187) 0.771   
History       
Heart failure history-No 82 4 1 (ref.)    
-Yes 17 8 9.647 (2.606-35.716) 0.001 9.698 (2.468-38.106) 0.001
CAD history -No 63 8 1 (ref.) - -  
-Yes 36 4 0.875 (0.246-3.110) 0.836   
MI history -No 91 10 1 (ref.) - -  
-Yes 8 2 2.275 (0.423-12.224) 0.338   
Family history of ACS 96 11 1 (ref.) - -  
-Yes 3 1 2.909 (0.278-30.430) 0.373   
Smoking 53 7 1 (ref.) - -  
-Yes 46 5 0.823 (0.245-2.770) 0.753   
  1. *On the basis of logistic regression, with statistical significance (p < 0.05) shown in bold.