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Table 4 Association between ACE I/D polymorphisms and ACS sudden cardiac death

From: Angiotensin converting enzyme DD genotype is associated with acute coronary syndrome severity and sudden cardiac death in Taiwan: a case-control emergency room study

Subject characteristics

Survival

Expired

Univariate

 

Multivariate

 
 

(n = 99)

(n = 12)

OR (95%CI)

p*

OR (95% CI)

p*

ACE-genotypes

      

II

35

2

1 (ref.)

 

1 (ref.)

 

ID

47

4

1.489 (0.258-8.595)

0.656

1.659 (0.264-10.427)

0.589

DD

17

6

6.176 (1.126-33.876)

0.036

6.484 (1.036-40.598)

0.046

ACS spectrum

      

UAP (n = 57)

54

3

1 (ref.)

   

AMI (n = 54)

45

9

3.600 (0.919-14.100)

0.066

  

Demographic factors

      

Age

65.02 ± 13.40

64.85 ± 17.90

0.999 (0.956-1.043)

0.949

-

-

Sex -Female

21

4

1 (ref.)

   

Male

78

8

1.857 (0.510-6.769)

0.348

-

-

Complications

      

Hypertension- No

36

5

1 (ref.)

 

-

-

- Yes

63

7

0.800 (0.237-2.706)

0.720

  

Diabetes Mellitus-No

68

7

1 (ref.)

 

-

-

- Yes

31

5

1.567 (0.461-5.327)

0.472

  

Hypercholesterolemia-No

78

11

  

-

-

- Yes

21

1

0.338 (0.041-2.766)

0.312

  

Other clinical risk factors

      

Systolic blood pressure

67

6

1(ref.)

 

-

-

< 140 mmHg

      

≥ 140 mmHg

32

6

2.094 (0.626-7.003)

0.230

  

Diastolic blood pressure

78

10

1 (ref.)

 

-

-

< 90 mmHg

      

≥ 90 mmHg

21

2

0.743 (0.151-3.653)

0.715

  

Total cholesterol

83

11

1 (ref.)

-

-

 

< 200 mg/dl

      

≥ 200 mg/dl

16

1

0.472 (0.057-3.913)

0.486

  

Triglyceride < 150 mg/dl

81

11

1 (ref.)

-

-

 

≥ 150 mg/dl

18

1

0.409 (0.050-3.374)

0.406

  

BMI (kg/m2) < 27

88

11

1 (ref.)

-

-

 

≥ 27

11

1

0.727 (0.085-6.187)

0.771

  

History

      

Heart failure history-No

82

4

1 (ref.)

   

-Yes

17

8

9.647 (2.606-35.716)

0.001

9.698 (2.468-38.106)

0.001

CAD history -No

63

8

1 (ref.)

-

-

 

-Yes

36

4

0.875 (0.246-3.110)

0.836

  

MI history -No

91

10

1 (ref.)

-

-

 

-Yes

8

2

2.275 (0.423-12.224)

0.338

  

Family history of ACS

96

11

1 (ref.)

-

-

 

-Yes

3

1

2.909 (0.278-30.430)

0.373

  

Smoking

53

7

1 (ref.)

-

-

 

-Yes

46

5

0.823 (0.245-2.770)

0.753

  
  1. *On the basis of logistic regression, with statistical significance (p < 0.05) shown in bold.