Figure 3

Inflammatory markers FN and VCAM-1 in the lesser and greater curvature of PAK HZ and PAK KO mice. Fibronectin (FN) [left panel] and VCAM-1 [right panel] were stained and imaged at 40X magnification in the lesser and greater curvatures of the PAK heterozygote (HZ) and knockout (KO) mice [Panels top to bottom]. Each section was imaged at 5 different locations within a curvature zone to cover the entire length of the greater (GC) and lesser curvature (LC), respectively. The bar graphs below each panel show the integrated density between the two strains in the region of the greater and lesser curvatures. Sample size was n = 6 for PAK HZ and n = 7 for PAK KO. “*” represents significance <0.05 as analyzed by independent Student t-test.