Table 1 Study outcomes, targets and measurements at T ₀ and T ₁

BMI

≤25; or at least 5% reduction of bodyweight

Height: measured without shoes, by nurse

Weight: measured without coat and shoes, by nurse

Waist circumference

♀ ≤ 88 cm, ♂ ≤ 102 cm

Measured by nurse with a measuring tape halfway between the lowest rib and the top of the hipbone around the abdomen, under (or without) clothing.

Physical activity

≥ 30 min. 5 times per week

Patient questionnaire: Physical Activity Scale for the Elderly (PASE; [20])

Systolic blood pressure

< 140 mmHg

Measured by nurse with an automatic sphygmomanometer. Patient is seated and both arms are measured. Measurement on the arm with the highest systolic blood pressure is repeated. The mean value of these both measurements is registered

Total cholesterol

≤ 5,0 mmol/l

Laboratory^*

LDL cholesterol

≤ 2,5 mmol/l

Laboratory

HDL cholesterol

≥ 1,0 mmol/l

Laboratory

Diet

2 ounces of vegetables, 2 pieces of fruit, 20–35% energy intake of fat; < 10% energy intake of saturated fat

Patient questionnaire: Maastricht Voedingsvragenlijst[21]

Secondary outcomes

Blood glucose

fasting glucose < 7 mmol/l

Laboratory

HbA1c (%)

< 53 mmol/mol (< 7%)

Laboratory

Smoking

fully quit

Patient questionnaire: Self report, one question

Self management

Patient questionnaire: Self report, five questions

Medication adherence

Full adherence

Patient questionnaire: Adapted Morisky Scale [22]

Quality of life

Patient questionnaire: MacNew Heart Disease Health-related Quality of Life Questionnaire [23]

Depression Anxiety

Patient questionnaire: Hospital Anxiety and Depression Scale (HADS; [24])