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Table 4 Comparison of the Aragon Workers’ Health Study to landmark cohort studies of subclinical cardiovascular imaging

From: Aragon workers’ health study – design and cohort description

Study

Aragon Workers’ Health Study (AWHS)

High-risk Plaque Initiative Biomage Study (HRP)[19]

Atherosclerosis Risk in Communities Study (ARIC)[39, 44]

Cardiovascular Health Study (CHS)[40]

Multi-Ethnic Study of Atherosclerosis (MESA)[41]

Sample size

5,400

7,687

15,792

5,888

5,800

Study population

Workers at an automobile assembly plant

Enrollees of a health plan free of CVD with at least 1 CVD risk factor

Probability sampling of household in participating communities

Probability sampling of Medicare elderly lists in participating communities

Volunteers free of CVD

Age range (y)

18 – 64

Men: 55 – 80

45 – 64

≥65

45 – 84

Women: 60 – 80

Baseline period

2009 – 2010

2008 – 2009

1987 – 1998

1989 – 1993

2000 – 2002

Imaging methods at baseline

US (2D + 3D) of carotid, abdominal aorta, femoral and iliac arteries

US (2D + 3D) of carotid arteries and abdominal aorta

US (2D) of carotid arteries

US (2D) of carotid arteries

US (2D) of carotid arteries and abodminal

  

ABI

ABI

aorta

CACS

CACS

Retinal photograph

CACS

ABI

ABI

ABI

CE-MRI

Cardiac MRI

CT-angiography [18] F-FDG PET/CT

Follow-up visits

Annual

No

Every 3 years

Annual through 1999

Every 2 years

2005 – 2006

Imaging methods during follow-up

Imaging methods repeated every 3 years

No

Imaging methods repeated every 3  years CE-MRI

Imaging methods repeated after 3 years

Imaging methods in subsamples

   

Retinal photograph

 

CE-MRI

  1. ABI: ankle-brachial blood pressure index; CACS: coronary artery calcium scoring; CE-MRI: contrast-enhanced magnetic resonance imaging; CT: computed tomography; CVD: cardiovascular disease; FDG: fluorodeoxyglucose; PET: positron emission tomography; US: ultrasound.