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Table 4 Comparison of the Aragon Workers’ Health Study to landmark cohort studies of subclinical cardiovascular imaging

From: Aragon workers’ health study – design and cohort description

Study Aragon Workers’ Health Study (AWHS) High-risk Plaque Initiative Biomage Study (HRP)[19] Atherosclerosis Risk in Communities Study (ARIC)[39, 44] Cardiovascular Health Study (CHS)[40] Multi-Ethnic Study of Atherosclerosis (MESA)[41]
Sample size 5,400 7,687 15,792 5,888 5,800
Study population Workers at an automobile assembly plant Enrollees of a health plan free of CVD with at least 1 CVD risk factor Probability sampling of household in participating communities Probability sampling of Medicare elderly lists in participating communities Volunteers free of CVD
Age range (y) 18 – 64 Men: 55 – 80 45 – 64 ≥65 45 – 84
Women: 60 – 80
Baseline period 2009 – 2010 2008 – 2009 1987 – 1998 1989 – 1993 2000 – 2002
Imaging methods at baseline US (2D + 3D) of carotid, abdominal aorta, femoral and iliac arteries US (2D + 3D) of carotid arteries and abdominal aorta US (2D) of carotid arteries US (2D) of carotid arteries US (2D) of carotid arteries and abodminal
   ABI ABI aorta
CACS CACS Retinal photograph CACS
CE-MRI Cardiac MRI
CT-angiography [18] F-FDG PET/CT
Follow-up visits Annual No Every 3 years Annual through 1999 Every 2 years
2005 – 2006
Imaging methods during follow-up Imaging methods repeated every 3 years No Imaging methods repeated every 3  years CE-MRI Imaging methods repeated after 3 years Imaging methods in subsamples
    Retinal photograph   CE-MRI
  1. ABI: ankle-brachial blood pressure index; CACS: coronary artery calcium scoring; CE-MRI: contrast-enhanced magnetic resonance imaging; CT: computed tomography; CVD: cardiovascular disease; FDG: fluorodeoxyglucose; PET: positron emission tomography; US: ultrasound.